Comparing two methods of wound irrigation for shoulder surgery

Cutibacterium Acnes Removal by Wound Irrigation With Normal Saline Versus Irrisept During Total Shoulder Arthroplasty

NA · Orthopaedic Education and Research Institute (dba Hoag Orthopedics) · NCT06379919

This study is testing whether using Normal Saline or Irrisept for cleaning wounds during shoulder surgery can help reduce bacteria and improve recovery for patients.

Quick facts

PhaseNA
Study typeInterventional
Enrollment126 (estimated)
Ages18 Years and up
SexAll
SponsorOrthopaedic Education and Research Institute (dba Hoag Orthopedics) (other)
Locations1 site (Orange, California)
Trial IDNCT06379919 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effectiveness of two different irrigation solutions, Normal Saline and Irrisept, in reducing Cutibacterium acnes contamination in patients undergoing Total Shoulder Arthroplasty. Participants will have bacteriologic cultures taken from subcutaneous and deep tissue before the irrigation procedure. Additionally, the study will assess patient-reported outcomes and range of motion related to the presence of C acnes in both groups. The goal is to determine which irrigation method is more effective in minimizing bacterial contamination.

Who should consider this trial

Good fit: Ideal candidates for this study are adult patients aged 18 and older who are scheduled for Total Shoulder Arthroplasty.

Not a fit: Patients with a history of shoulder infection, those currently on antibiotic therapy, or individuals who are immunocompromised may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical outcomes and reduced infection rates for patients undergoing shoulder surgery.

How similar studies have performed: Other studies have explored various irrigation methods in surgical settings, but this specific comparison of Irrisept and Normal Saline is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

• Ault patients requiring Total Shoulder Arthroplasty

Exclusion Criteria:

* Age younger than 18 years
* History of shoulder infection
* Antibiotic therapy within 2 weeks of surgery
* Cortisone infiltration within 3 months prior to surgery
* Allergy to CHG
* Diagnosis of rheumatoid arthritis
* Immunocompromised patients

Where this trial is running

Orange, California

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Cutibacterium Acnes Contamination

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.