Comparing two methods of therapy for PTSD using virtual reality and treadmill walking
Official title: Computer Monitor Versus Augmented Reality: Expanding 3MDR Therapy for PTSD
Run by Uniformed Services University of the Health Sciences · NCT05244564 · Data updated 2026-11-12
This study is testing two different ways of using virtual reality and treadmill walking to help people with PTSD feel better through a special therapy called 3MDR.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Uniformed Services University of the Health Sciences Federal |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | April 30, 2023 |
| Main results expected | May 31, 2027 |
| Study ends | October 30, 2027 |
| Registry record updated | July 15, 2025 |
| Trial ID | NCT05244564 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are service members, veterans, retirees, or eligible dependents aged 18 and older with a confirmed diagnosis of PTSD.
✕Probably not a fit
Patients with a history of epilepsy, psychotic disorders, or those currently using benzodiazepines may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial is a prospective randomized controlled trial that compares two methods of delivering Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR) therapy for individuals with post-traumatic stress disorder (PTSD). The study will enroll 60 eligible volunteers from the Department of Defense healthcare system, who will participate in 10-14 therapy sessions lasting 60-90 minutes each. Participants will walk on a treadmill while engaging with a therapist and integrating chosen pictures and music into a virtual reality environment. The effectiveness of the two delivery methods will be assessed before therapy, immediately after, and at 3 and 6 months post-therapy.
Why it matters
Potential benefit: If successful, this study could provide a more accessible and effective treatment option for patients suffering from PTSD.
How similar studies have gone: Previous studies have shown the effectiveness of the 3MDR approach in treating PTSD symptoms, indicating a promising avenue for this trial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Service member, veteran, retiree, or DEERS-eligible dependent, male or female, at least 18 years or older * Diagnosis of PTSD, as confirmed by the CAPS-5 * Able to ambulate with contact guard assistance or less, and walk unassisted on a treadmill, at a normal pace, for up to 90 minutes continuously Exclusion Criteria: * History of epilepsy or a seizure disorder, other than febrile seizures that occurred during childhood and have not recurred since * History of a psychotic disorder, bipolar disorder, or active suicidal or homicidal ideation * Use of benzodiazepines on a regular basis within the previous 30 days
Where it's running
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Uniformed Services University
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Michael Roy, MD, MPH — Unformed Services University
- Study coordinator: Hannah Attalah, BA
- Email: care4ptsd@gmail.com
- Phone: 301-412-8187
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.