Comparing two methods of pain relief during labor in first-time mothers
Official title: Impact of Programmed Intermittent Epidural Bolus Compared With Continuous Epidural Infusion on Breakthrough Pain Among Laboring Nulliparous Women. A Randomized Controlled Trial
Run by Holy Family Hospital, Nazareth, Israel · NCT06494280 · Data updated 2026-11-12
This study is testing whether a new way of giving epidural pain relief during labor can help first-time moms feel less pain and be more satisfied compared to the traditional method.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | Women only |
| Enrollment | 240 (estimated) |
| Sponsor | Holy Family Hospital, Nazareth, Israel Academic / other |
| Locations | 1 site (Nazareth) |
| Status | Recruiting |
| Started | September 10, 2024 |
| Main results expected | November 2026 |
| Study ends | December 2026 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT06494280 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are nulliparous women in the latent phase of labor with a singleton vertex presentation who request epidural analgesia.
✕Probably not a fit
Patients who may not benefit include those with contraindications for epidural analgesia or complications such as estimated fetal weight over 4 kg.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of programmed intermittent bolus epidural analgesia (PIBEA) versus continuous epidural infusion (CEI) in managing breakthrough pain during labor in nulliparous women. Participants will be randomly assigned to receive either PIBEA, which delivers pain relief at scheduled intervals, or CEI, which provides a continuous dose. The study will assess outcomes such as the incidence of breakthrough pain, labor duration, and overall satisfaction with pain management. The goal is to determine if PIBEA can improve pain relief and reduce the need for additional interventions compared to CEI.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain management during labor and enhance the overall experience for first-time mothers.
How similar studies have gone: Previous studies have shown promising results for similar techniques in pain management during labor, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Nulliparous women * Term pregnancy * Singleton * Vertex presentation * Latent phase (cervical dilatation \<6 cm) * Epidural analgesia request * Visual Analogue Scale score \> 40 Exclusion Criteria: * Estimated fetal weight \> 4 kg * Intra uterine fetal death * Drug sensitivity * Anomalous fetus * Contraindication for epidural analgesia
Where it's running
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Holy Family Hospital
Nazareth, Israel Recruiting
Study contacts
- Study coordinator: Raed Salim, MD
- Email: r.salim@hfhosp.org
- Phone: +972544986960
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.