Comparing two methods for regenerating dental pulp in young teeth
Evaluation of Demineralized Dentin Matrix as a Scaffold for Revascularization in Immature Permanent Incisors: A Randomized Controlled Trial and an In -Vitro Study
This study is testing whether using a special scaffold made from demineralized dentin or a blood clot can help young teeth with dead nerves heal better over a year.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 7 Years to 13 Years |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo, Alabbassia) |
| Trial ID | NCT06006052 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the clinical and radiographic outcomes of using a demineralized dentin matrix scaffold versus a blood clot scaffold in treating immature permanent incisors with non-vital pulps over a one-year period. It also investigates the effects of the demineralized dentin matrix on dental pulp stem cells in vitro. The goal is to enhance the regenerative endodontic techniques that can lead to better long-term outcomes for teeth affected by necrosis. By utilizing these biologically based techniques, the study seeks to improve root lengthening and apical closure, which are critical for the preservation of immature teeth.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 7-13 years with at least one immature permanent anterior tooth diagnosed with irreversible pulpitis or pulp necrosis.
Not a fit: Patients with root fractures, significant periapical radiolucency, or developmental anomalies of the root may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for children with dental trauma, potentially improving tooth longevity and health.
How similar studies have performed: Previous studies have shown high success rates for regenerative endodontic techniques, indicating that this approach has been effective in similar contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria : patients clinical examination Must be include the following * Patients aged 7-13years at the time of enrolment. * Provision of informed consent by one parent or legal guardian. * At least the patents have one immature permanent anterior tooth diagnosed with irreversible pulpitis or pulp necrosis with or without periapical lesions. * Restorable teeth ,clinical crown should be enough to use rapper dam Compliant patient/parent. * Patients are not allergic to medicaments and antibiotics necessary to complete the procedure (ASA 1 or 2). * Radiologic evidence of open apices (Teeth are considered immature when a minimum of 0.8 mm apical foramen width is evident) * Exclusion Criteria: * the patients will excluded if one of the following criteria is present in the patients * Teeth with root fractures. * Presence of internal or external root resorptions. * Developmental anomalies of the root. * Presence of periapical radiolucency more than 10 mm. * Tooth with class III mobility.
Where this trial is running
Cairo, Alabbassia
- Ain shams university — Cairo, Alabbassia, Egypt (Recruiting)
Study contacts
- Study coordinator: Marwa Abozed
- Email: marwaabozed@dent.asu.edu.eg
- Phone: 00201142621411
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.