Comparing two methods for preparing the uterus for frozen embryo transfer in women with adenomyosis
The Effectiveness of the Two Different Endometrial Preparation Regimes for Frozen Embryo Transfer in Patients With Adenomyosis
NA · Mỹ Đức Hospital · NCT06239376
This study tests two different ways to prepare the uterus for frozen embryo transfer in women with adenomyosis to see which one helps achieve more successful pregnancies.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 222 (estimated) |
| Ages | 18 Years to 42 Years |
| Sex | Female |
| Sponsor | Mỹ Đức Hospital (other) |
| Locations | 1 site (Ho Chi Minh City, Ho Chi Minh City) |
| Trial ID | NCT06239376 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of two different endometrial preparation protocols for frozen embryo transfer (FET) in women diagnosed with adenomyosis. Participants will be randomly assigned to receive either a regimen that includes a GnRH agonist and letrozole or a standard protocol using exogenous steroids alone. The study aims to determine which approach leads to higher live birth rates and to assess the side effects associated with the GnRH agonist treatment. The trial is designed to provide insights into optimal treatment strategies for improving reproductive outcomes in this patient population.
Who should consider this trial
Good fit: Ideal candidates are women aged 18 to 42 with a confirmed diagnosis of adenomyosis who are preparing for frozen embryo transfer.
Not a fit: Patients with uterine abnormalities or contraindications to hormone therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve live birth rates for women with adenomyosis undergoing frozen embryo transfer.
How similar studies have performed: There have been no randomized controlled trials specifically investigating these endometrial preparation protocols in women with adenomyosis, making this approach novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirm diagnosis with adenomyosis by using transvaginal ultrasonography (MUSA consensus) and/or pelvic magnetic resonance imaging. * Age between 18 - 42 * Undergo less or equal to three previous IVF cycles * Indicate for frozen embryo transfer * Agree to have not more than two day-3 embryo or one blastocyst (day-5 and day-6) transferred * Not participating in any other study Exclusion Criteria: * Embryos from IVM cycle * Having uterine or adnexal abnormalities (e.g., intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx, endometrial polyp, submucosal leiomyoma, or leiomyoma with endometrial cavity distortion) * Having contraindications for exogenous hormones administration: breast cancer, risks of venous thromboembolism * Embryos from the oocyte donation cycle. * Patients with a history of GnRH injection within three months, measured from the last GnRHa injection to the study screening date.
Where this trial is running
Ho Chi Minh City, Ho Chi Minh City
- My Duc Hospital — Ho Chi Minh City, Ho Chi Minh City, Vietnam (RECRUITING)
Study contacts
- Principal investigator: Lan N Vuong, MD, PhD — University of Medicine and Pharmacy at Ho Chi Minh City
- Study coordinator: Tien K Le, MD
- Email: bstien.lk@myduchospital.vn
- Phone: +84962803875
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Adenomyosis, IVF, Frozen Embryo Transfer