Comparing two methods for preparing the uterus for frozen embryo transfer in women with adenomyosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of two different endometrial preparation protocols for frozen embryo transfer (FET) in women diagnosed with adenomyosis. Participants will be randomly assigned to receive either a regimen that includes a GnRH agonist and letrozole or a standard protocol using exogenous steroids alone. The study aims to determine which approach leads to higher live birth rates and to assess the side effects associated with the GnRH agonist treatment. The trial is designed to provide insights into optimal treatment strategies for improving reproductive outcomes in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Confirm diagnosis with adenomyosis by using transvaginal ultrasonography (MUSA consensus) and/or pelvic magnetic resonance imaging.
* Age between 18 - 42
* Undergo less or equal to three previous IVF cycles
* Indicate for frozen embryo transfer
* Agree to have not more than two day-3 embryo or one blastocyst (day-5 and day-6) transferred
* Not participating in any other study

Exclusion Criteria:

* Embryos from IVM cycle
* Having uterine or adnexal abnormalities (e.g., intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx, endometrial polyp, submucosal leiomyoma, or leiomyoma with endometrial cavity distortion)
* Having contraindications for exogenous hormones administration: breast cancer, risks of venous thromboembolism
* Embryos from the oocyte donation cycle.
* Patients with a history of GnRH injection within three months, measured from the last GnRHa injection to the study screening date.

Where it's running

• My Duc Hospital
  Ho Chi Minh City, Ho Chi Minh City, Vietnam Recruiting

Study contacts

• Principal investigator: Lan N Vuong, MD, PhD — University of Medicine and Pharmacy at Ho Chi Minh City
• Study coordinator: Tien K Le, MD
• Email: bstien.lk@myduchospital.vn
• Phone: +84962803875

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.