Comparing two methods for oocyte collection in women with low ovarian reserve

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of a Dydrogesterone-primed ovarian stimulation (DPOS) protocol against a GnRH antagonist protocol for oocyte accumulation in women with diminished ovarian reserve. Eligible participants, aged 18 to 37 with low ovarian reserve indicators, will be randomly assigned to one of the two treatment groups. Both groups will undergo a standardized ovarian stimulation regimen, followed by oocyte retrieval and cryopreservation. The study is designed to assess which protocol yields a higher number of viable oocytes for future use in assisted reproductive technology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Woman aged between 18 and 37 years
* AFC ≤ 5 and/or AMH ≤ 1.2 ng/ml
* Agree to perform freeze-all strategy and single frozen blastocyst embryo transfer

Exclusion Criteria:

* Oocyte recipient
* Indication of preimplantation genetic testing
* Known allergic reactions to medications in the Study (progesterone products, GnRH antagonist….)
* Basal FSH above 15mIU/mL.
* Have contraindications of ART treatment (e.g. critical or acute diseases)
* Retrieved sperm
* Repeated Implantation failure ( ≥ 3 failed embryo transfers with good-quality embryos)
* Inability to comply with the study procedures.
* Patients with a history of thyroid cancer who are on hormone replacement therapy or those diagnosed with thyroid diseases at the time of eligibility assessment

Where it's running

• Ivfta
  Hanoi, Hanoi, Vietnam Recruiting
• Ivfta Hcmc
  Ho Chi Minh City, Ho Chi Minh, Vietnam Recruiting

Study contacts

• Principal investigator: Nhu H Giang, MD., MCE — Tam Anh TP. Ho Chi Minh General Hospital
• Study coordinator: Nhu H Giang, MD., MCE
• Email: nhugh@tahospital.vn
• Phone: +84 793 231 721

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.