Comparing two methods for finding and treating tuberculosis in Uganda
Clinic Versus Hotspot Active Case Finding and Linkage to Preventive Therapy (ACF/TPT) Strategy Evaluation for TB: A Cluster-Randomized Crossover Trial
NA · Johns Hopkins University · NCT05285202
This study is testing two different ways to find and treat tuberculosis in Uganda to see which method works better for getting people diagnosed and linked to care.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 150000 (estimated) |
| Ages | 5 Years and up |
| Sex | All |
| Sponsor | Johns Hopkins University (other) |
| Locations | 1 site (Kampala) |
| Trial ID | NCT05285202 on ClinicalTrials.gov |
What this trial studies
This five-year study evaluates two strategies for active case finding (ACF) and linkage to tuberculosis (TB) treatment in peri-urban Uganda. One strategy focuses on facility-based ACF, recruiting individuals attending a large public health facility, while the other targets identified TB hotspots in the community. Both strategies aim to improve the detection and treatment of TB by utilizing local data and resources. The study will assess the effectiveness of these approaches in increasing TB diagnosis and preventive therapy linkage.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 15 and older, or children aged 5-14 who are close contacts of someone diagnosed with TB.
Not a fit: Patients currently undergoing treatment for active TB or those diagnosed but not yet treated will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly improve TB detection and treatment rates in underserved populations.
How similar studies have performed: Other studies have shown success with similar community-based approaches to TB case finding, indicating potential for effective outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥15 years, OR age 5-14 and a close contact of someone diagnosed with TB, * Provision of oral informed consent, or, if age \<18 years and not legally emancipated, oral informed assent (if ages 8-17) and parental informed consent (ages 5-17) to participate in the study * Ability to communicate with study staff in English or Luganda, or availability of a capable interpreter who is acceptable to the participant Exclusion Criteria: * On treatment for, or diagnosed with but not yet treated for, active TB
Where this trial is running
Kampala
- Walimu — Kampala, Uganda (RECRUITING)
Study contacts
- Principal investigator: Emily Kendall, MD PhD — Johns Hopkins University
- Study coordinator: Emily A Kendall, MD PhD
- Email: ekendall@jhmi.edu
- Phone: 410-502-8234
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Tuberculosis, Pulmonary, Mycobacterium Tuberculosis Infection