Comparing two methods for coronary artery bypass grafting
A Prospective, Randomized Comparison of Coronary Artery Bypass Grafting Based on COmputed Tomography-derived Fractional Flow REserve Versus Angiography (CABG-COREA Trial)
This study is testing which method of heart surgery works better for people with coronary artery disease by comparing traditional imaging to a newer technique to see how well the grafts stay open over time.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 96 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | Myongji Hospital Academic / other |
| Locations | 1 site (Goyang-si, Gyeonggi-do) |
| Trial ID | NCT06028165 on ClinicalTrials.gov |
What this trial studies
This trial aims to compare the effectiveness of coronary artery bypass grafting (CABG) based on conventional coronary angiography versus cardiac computed tomography-derived fractional flow reserve in patients with coronary artery disease. It is a randomized, controlled trial involving 96 patients who will be assigned to one of the two methods for revascularization. The primary focus is on evaluating early and one-year graft patency rates, while secondary outcomes include overall survival and freedom from major adverse cardiac or cerebrovascular events.
Who should consider this trial
Good fit: Ideal candidates are patients aged 40 to 80 who require CABG due to multi-vessel coronary artery disease.
Not a fit: Patients with severe heart failure, significant arrhythmias, or other serious comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved graft patency rates and better clinical outcomes for patients undergoing CABG.
How similar studies have performed: Other studies have shown promising results with similar approaches, indicating potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age equal or more than 40 * age equal or less than 80 * patients who undergo coronary artery bypass grafting due to multi-vessel coronary artery disease * patients who agree to the enrollment Exclusion Criteria: * Patients with heart failure (left ventricular ejection fraction \< 25%) * patients who have intractable ventricular arrhythmia * patients who has been treated for cancer * patients who has infectious disease * patients who are planned to undergo combined cardiac surgery * patients who has medical co-morbidity with expected survival less than 1 year * patients with a history of previous cardiac surgery * Patients with chronic renal failure requiring dialysis * patients who undergo emergency operation
Where this trial is running
Goyang-si, Gyeonggi-do
- Myongji Hospital — Goyang-si, Gyeonggi-do, South Korea (Recruiting)
Study contacts
- Study coordinator: Min-Seok Kim, MD, PhD, MSc
- Email: minseok.kim.md.phd@gmail.com
- Phone: 82-10-8482-0380
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.