Comparing two medications for managing blood pressure and shivering during cesarean deliveries
Comparative Study Between Intravenous Granisetron and Ondansetron on Their Effect on Hemodynamics and Shivering After Spinal Anesthesia in Elective Cesarean Delivery : A Randomized Double-Blind Study
This study tests whether two medications can help control blood pressure and reduce shivering in women having a cesarean delivery with spinal anesthesia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Sex | Female |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag) |
| Trial ID | NCT06437236 on ClinicalTrials.gov |
What this trial studies
This study compares the effects of intravenous granisetron and ondansetron on hemodynamics and shivering in patients undergoing elective cesarean deliveries with spinal anesthesia. It aims to address the common adverse effects of spinal anesthesia, such as hypotension and shivering, which can lead to serious complications for both the mother and the neonate. By evaluating the effectiveness of these two medications, the study seeks to improve maternal and neonatal outcomes during cesarean sections.
Who should consider this trial
Good fit: Ideal candidates for this study are pregnant women scheduled for elective cesarean delivery under spinal anesthesia.
Not a fit: Patients who have significant neurological or psychological diseases, known allergies to the study medications, or those with ischemic heart disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the safety and comfort of mothers undergoing cesarean deliveries by effectively managing hemodynamic instability and shivering.
How similar studies have performed: While there have been studies on managing spinal anesthesia effects, this specific comparison of granisetron and ondansetron is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All parturient who underwent elective caesarean delivery under spinal anesthesia will be included in this study Exclusion Criteria: * 1\. Patient refusal 2. Patient with significant neurological , psychological disease 3. patient known allergy to ondansetron or granisetron, 4. patients receiving serotonin agonists or antagonists, 5. patient ischemic heart disease, chronic hypertension or pregnancy induced hypertension
Where this trial is running
Sohag
- Sohag university Hospital — Sohag, Egypt (Recruiting)
Study contacts
- Study coordinator: mohamed A A, resident
- Email: mohamedreshwan@med.sohag.edu.eg
- Phone: 01030026022
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.