Comparing two local anesthetics for cesarean sections
Official title: Intrathecal Use of Chloroprocaine 1% and Ropivacaine 0,75% During Elective Cesarean Section. A Comparative Study
Run by Aretaieion University Hospital · NCT06376058 · Data updated 2026-11-12
This study is testing whether a new local anesthetic called chloroprocaine works better than the usual one, ropivacaine, for women having cesarean sections.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 48 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Aretaieion University Hospital Academic / other |
| Locations | 1 site (Athens) |
| Status | Recruiting |
| Started | January 10, 2024 |
| Main results expected | January 10, 2026 |
| Study ends | January 10, 2026 |
| Registry record updated | July 22, 2025 |
| Trial ID | NCT06376058 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult women with singleton pregnancies who are scheduled for elective cesarean sections and have an ASA classification of I-II.
✕Probably not a fit
Patients who may not benefit from this study include those with high ASA classifications, multiple gestations, or any contraindications for regional anesthesia.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare the effectiveness of chloroprocaine 1% and ropivacaine 0.75% when administered intrathecally during elective cesarean sections. It is a prospective randomized study that will evaluate the anesthetic outcomes of both drugs in parturients undergoing combined spinal-epidural anesthesia. The study seeks to determine if the newer formulation of chloroprocaine, which is now considered safe, can provide advantages over the commonly used ropivacaine. The trial will include adult women with singleton pregnancies who meet specific health criteria.
Why it matters
Potential benefit: If successful, this study could provide a safer and more effective anesthetic option for women undergoing cesarean sections.
How similar studies have gone: While chloroprocaine has been used in the past, its recent reformulation makes this approach novel and untested in the context of elective cesarean sections.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult parturients, American Society of Anesthesiologists (ASA) I-II, * singleton gestation\>37 weeks * elective cesarean section Exclusion Criteria: * American Society of Anesthesiologists (ASA) \> III * age \< 18 years * singleton gestation \<37 weeks * Body Mass Index (BMI) \>40 kg/m2 * Body weight \<50 kg * Body weight\>100 kg * height\<150 cm * height\>180 cm * multiple gestation * emergency delivery * fetal abnormality * fetal distress * pregnancy-induced pathology such as preeclampsia, eclampsia, premature labor, placental abnormalities * pregnancy- induced diseases such as hepatic failure, pseudocholinesterase deficiency, neuromuscular diseases * lack of informed consent * contraindication for regional anesthesia such as thrombocytopenia, coagulation abnormalities, allergy to local anesthetics
Where it's running
-
Aretaieion University Hospital
Athens, Greece Recruiting
Study contacts
- Principal investigator: Kassiani Theodoraki, PhD, DESA — Aretaieion University Hospital
- Study coordinator: Kassiani Theodoraki, PhD, DESA
- Email: ktheodoraki@hotmail.com
- Phone: 6974634162
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Effects of massage and exercises on cesarean scar and recovery
This study tests whether direct scar massage or indirect massage plus exercise helps people recover after a cesarean birth and reduces scar-related pain.
-
Reflexology and hand massage after cesarean section
This study tests whether reflexology hand massage or stroking hand massage can reduce anxiety and increase satisfaction, and how they affect heart/blood pressure after cesarean delivery.
-
Health education to see if primigravida women choose vaginal delivery more often
A health education program is being tested to see if it helps first-time pregnant women in choosing vaginal delivery over unnecessary cesareans.
-
Enhanced Recovery Adherence and Recovery Quality After Cesarean Delivery
This study tests whether following enhanced recovery after cesarean delivery protocols is linked with better recovery quality in women having a planned cesarean with spinal anesthesia.
-
Predictors of severe pain within 24 hours after cesarean delivery with spinal anesthesia
This study will look at which pre-, intra-, and post-operative factors are linked to severe pain in the first 24 hours after an elective cesarean done with spinal anesthesia.
-
Steri-Strips added to standard wound closure after cesarean delivery
This study tests whether adding Steri-Strips after a C-section helps reduce wound problems for pregnant patients.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.