Comparing two laser techniques for treating kidney and ureteral stones
Comparison of Ureteroscopy With High-powered Holmium:Yag Laser Lithotripsy With and Without Moses 2.0 Pulse Modulation
This study is testing whether a new laser technique for breaking up kidney and ureteral stones works better than the standard method for people with stones between 6mm and 20mm.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Northwestern University Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT06346483 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effectiveness of Moses 2.0 pulse modulation technology against standard high-powered Holmium laser lithotripsy in treating kidney and ureteral stones sized between 6mm and 20mm. Participants will be randomly assigned to receive one of the two treatments during ureteroscopy, with the goal of evaluating differences in operating room time, laser usage, energy consumption, and stone-free rates. Follow-up imaging will be conducted 8 to 12 weeks post-surgery to assess for any remaining stones or complications. The study seeks to provide insights into the optimal use of laser technology for stone fragmentation.
Who should consider this trial
Good fit: Ideal candidates are adults undergoing ureteroscopy for kidney or ureteral stones sized between 8mm and 20mm.
Not a fit: Patients with staged surgeries, nephrocalcinosis, or those under 18 years of age may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment outcomes and efficiency in the management of kidney and ureteral stones.
How similar studies have performed: While the Moses 2.0 technology is FDA approved and in use, this specific comparison of modulation techniques has not been previously studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing ureteroscopy and laser lithotripsy * Stone size ≥8 but \< 20 mm in the proximal ureter or kidney. Multiple stones ≤4 are allowed. Bilateral surgeries are allowed * Willing to sign informed consent Exclusion Criteria: * Staged surgery * Nephrocalcinosis * Participant is less than 18 years of age * Inability to provide informed consent * Members of vulnerable patient populations
Where this trial is running
Chicago, Illinois
- Northwestern Medicine — Chicago, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Amy Krambeck, MD — Northwestern University
- Study coordinator: Alyssa McDonald, MPH
- Email: alyssa.mcdonald@northwestern.edu
- Phone: 312-695-8146
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.