Comparing two imaging techniques for detecting right-sided colon polyps during screening colonoscopy
A Randomized Comparison Between White Light Endoscopy (WLE) and Bright Narrow Band Imaging (B-NBI) in the Diagnosis of Right Sided Colonic Polyps in Asymptomatic Subjects Undergoing Screening Colonoscopy
This study is testing whether a special type of camera called narrow band imaging can find more right-sided colon polyps than regular white light during screening colonoscopies for people who don’t have symptoms.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Western Sydney Local Health District Academic / other |
| Locations | 1 site (Sydney, New South Wales) |
| Trial ID | NCT05935124 on ClinicalTrials.gov |
What this trial studies
This study is a randomized controlled crossover trial aimed at determining whether narrow band imaging (NBI) or white light endoscopy (WLE) is more effective in detecting right-sided colonic polyps in asymptomatic individuals undergoing screening colonoscopy. The research addresses the challenge of missed colorectal adenomas, particularly in the proximal colon, where detection rates are lower. Participants will first undergo WLE followed by NBI to compare the adenoma detection rates between the two methods. The study seeks to enhance colonoscopy performance and improve early detection of colorectal cancer.
Who should consider this trial
Good fit: Ideal candidates for this study are asymptomatic individuals over the age of 50 who are at average risk for colorectal cancer.
Not a fit: Patients with a personal history of inflammatory bowel disease, colon adenoma or cancer, or a family history of colorectal cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved detection rates of colorectal adenomas, potentially reducing the incidence of colorectal cancer.
How similar studies have performed: Previous studies have shown mixed results regarding the effectiveness of narrow band imaging compared to white light endoscopy, indicating that while some studies suggest NBI may improve detection rates, others have found no significant difference.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Asymptomatic subjects undergoing screening colonoscopy * age \> 50. * average risk subjects defined as those without a personal history of inflammatory bowel disease, colon adenoma or cancer or family history of FAP or Familial non-polyposis syndrome or first degree relatives having diagnosed to have colo-rectal carcinoma, no colonoscopy in past 5 years and, ability to provide a written consent to trial participation Exclusion Criteria: * unable to consent
Where this trial is running
Sydney, New South Wales
- Westmead Hospital — Sydney, New South Wales, Australia (Recruiting)
Study contacts
- Study coordinator: Michael Bourke, MBBS
- Phone: 8890555
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.