Comparing two graft types for preserving bone after tooth extraction in the esthetic zone
Evaluation of Post Extraction Hard Tissue Alteration Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft: A Randomized Controlled Clinical Trial.
This study is testing whether using a special type of bone graft made from your own teeth works better than a graft from another species to help preserve the bone after a tooth extraction in the front of your mouth.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 23 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06552793 on ClinicalTrials.gov |
What this trial studies
This study evaluates the differences in clinical, radiographic, and histomorphometric outcomes between using a partially demineralized autogenous dentin graft and a xenograft for ridge preservation in the esthetic zone following tooth extraction. Patients with non-restorable teeth will undergo atraumatic extraction, followed by the application of one of the graft types to assess hard tissue changes over a six-month follow-up period. The research is conducted at the Faculty of Dentistry, Cairo University, focusing on alveolar bone regeneration procedures related to implant dentistry.
Who should consider this trial
Good fit: Ideal candidates are healthy adults over 18 with non-restorable teeth in the esthetic zone and good oral hygiene.
Not a fit: Patients with systemic conditions affecting healing, poor oral hygiene, or severe periodontal destruction may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve outcomes in bone preservation techniques, leading to better aesthetic results and implant success rates for patients.
How similar studies have performed: Previous studies have shown promising results with similar grafting techniques, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with non-restorable teeth and Type II extraction socket in the esthetic zone indicated for extraction for periodontal, carious or traumatic reasons. * Healthy patients with adequate oral hygiene (bleeding on probing ≤20%; Plaque index ≤20%). * Adult patients above 18 years old. * Patients accept 6-months follow-up period and provide an informed consent. Exclusion Criteria: * Heavy smokers (more than 10 cigarettes per day or an electronic cigarette dose of \>6 mg/ml of nicotine). * Patients reporting systemic conditions that may compromise healing or bone metabolism (eg: diabetes). * Patients with poor oral hygiene (bleeding on probing \>20%; Plaque index \>20%) * The presence of acute periapical infection. * The presence of severe periodontal destruction.
Where this trial is running
Cairo
- Faculty of Dentistry Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Riham A Alshikh Hani Alkurdee, Bachelor — Cairo University
- Study coordinator: Riham A Alshikh Hani Alkurdee, Bachelor
- Email: riham.ahmad@dentistry.cu.edu.eg
- Phone: +201021931950
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.