Comparing two doses of local anesthetics for breast cancer surgery anesthesia
Ultrasound-guided Subpectoral Plexus Block With Multi-level Thoracic Paravertebral Block for Surgical Anaesthesia During Primary Breast Cancer Surgery: A Prospective Randomized Double-blind Trial
NA · Chinese University of Hong Kong · NCT04933266
This study is testing whether using a higher dose of local anesthetic can help women having breast cancer surgery feel less pain and recover better.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Chinese University of Hong Kong (other) |
| Locations | 1 site (Sheung Shui, New Territories) |
| Trial ID | NCT04933266 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effectiveness of two different doses of local anesthetics (10ml vs 20ml of 0.25% levobupivacaine) for subpectoral plexus block in conjunction with ultrasound-guided multi-level thoracic paravertebral block for surgical anesthesia during major primary breast cancer surgeries. The research focuses on improving postoperative pain management and reducing the need for rescue analgesia by targeting a broader range of pain signals. By evaluating the effectiveness of these two doses, the study seeks to optimize anesthesia protocols for breast cancer surgeries, which are often performed under general anesthesia. The goal is to enhance patient recovery and minimize complications associated with postoperative pain.
Who should consider this trial
Good fit: Ideal candidates for this study are patients scheduled for mastectomy, modified radical mastectomy, or breast-conserving surgery with lymph node biopsy.
Not a fit: Patients with local skin site infections, coagulopathy, or allergies to local anesthetics may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve pain management and recovery outcomes for patients undergoing breast cancer surgery.
How similar studies have performed: While regional anesthesia techniques have been explored in breast cancer surgeries, this specific combination of subpectoral plexus block and multi-level thoracic paravertebral block with varying doses is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * scheduled for mastectomy, modified radical mastectomy or breast conservative surgery with lymph node biopsy and with or without axillary dissection Exclusion Criteria: * local skin site infection * coagulopathy * history of allergy to local anesthetics
Where this trial is running
Sheung Shui, New Territories
- North District Hospital — Sheung Shui, New Territories, Hong Kong (RECRUITING)
Study contacts
- Principal investigator: Manoj K Karmakar, MD — Chinese University of Hong Kong
- Study coordinator: Ayla Wong, RN, BN
- Email: aylawong@cuhk.edu.hk
- Phone: 3505 6157
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Breast Cancer, Subpectoral plexus block, Thoracic paravertebral block, Primary breast cancer surgery