Comparing two chemotherapy regimens for children with advanced kidney tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of two different chemotherapy regimens for children diagnosed with stage IV nephroblastoma, a type of kidney cancer. The standard treatment involves a combination of vincristine, actinomycin-D, and doxorubicin, while the experimental arm tests a regimen of vincristine, carboplatin, and etoposide. Patients will receive neoadjuvant chemotherapy before surgery, followed by risk-based adjuvant treatment. The study seeks to determine if the experimental regimen can improve outcomes for patients with metastatic disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* suffering from metastatic renal tumour at initial diagnosis
* having at least one circumscript, non-calcified (pulmonary) nodule (or other lesion highly suspicious of metastasis according to criteria for metastatic disease) ≥ 3 mm as determined by chest CT-scan and abdominal CT-scan/MRI.
* Metastatic disease must be confirmed by central review.

Exclusion Criteria:

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Where it's running

• Assistance Publique Hopitaux de Marseille
  Marseille, France Recruiting

Study contacts

• Study coordinator: Arnauld VERSCHUUR
• Email: arnauld.verschuur@ap-hm.fr
• Phone: +33.491.38.84.78

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.