Comparing two breathing methods during endoscopy of the pharynx, larynx, and oesophagus
OPTIGO /Comparison of Two Ventilation Methods During Endoscopy of the Pharynx, Larynx and Oesophagus: Multicentre, Randomised, Non-inferiority Trial
NA · Poitiers University Hospital · NCT07004699
It will test whether keeping adults breathing on their own with high-flow oxygen or using standard ventilation makes endoscopy of the throat and oesophagus safer and easier.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 610 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Poitiers University Hospital (other) |
| Drugs / interventions | chemotherapy |
| Locations | 2 sites (Poitiers and 1 other locations) |
| Trial ID | NCT07004699 on ClinicalTrials.gov |
What this trial studies
Adults scheduled for an exclusive endoscopy of the pharynx, larynx and oesophagus at CHU de Poitiers will be assigned to one of two ventilation strategies during the procedure: spontaneous ventilation supported by high-flow oxygen or conventional ventilation under general anaesthesia. The trial monitors intraoperative oxygenation, airway visibility, procedural conditions and immediate safety outcomes. Patients with combined procedures, severe obesity, or advanced COPD are excluded to reduce risk and improve comparability. Results will show whether one method provides better visibility and safety during these diagnostic or therapeutic endoscopies.
Who should consider this trial
Good fit: Adults (18+) who do not require supplemental oxygen and are scheduled for an exclusive endoscopy of the pharynx, larynx and oesophagus and can give informed consent.
Not a fit: Patients having combined procedures, with BMI ≥35, stage IV COPD, or known allergy to remifentanil, propofol, or lidocaine are excluded and unlikely to benefit from the tested ventilation strategies.
Why it matters
Potential benefit: If successful, the tested approach could improve airway visibility and oxygen safety during endoscopy and may reduce the need for more invasive ventilation for some patients.
How similar studies have performed: High-flow nasal oxygen and spontaneous ventilation have been used in airway procedures with promising oxygenation and visibility results, but direct comparative evidence remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged 18 or over. * Not requiring oxygen. * About to undergo exclusive Endoscopy of the pharynx, larynx and oesophagus surgery. * Score de l'American Society of Anesthesiology between 1 and 4 * Informed consent signed Exclusion Criteria: * Endoscopy of the pharynx, larynx and oesophagus surgery combined with another procedure * Severe or morbid obesity (BMI ≥ 35 kg/m²) * Patients with stage IV chronic obstructive pulmonary disease * Allergy to one of the drugs used in anaesthesia, remifentanil and/or propofol and/or lidocaine.
Where this trial is running
Poitiers and 1 other locations
- CHU Poitiers — Poitiers, France (RECRUITING)
- CHU de Poitiers — Poitiers, France (NOT_YET_RECRUITING)
Study contacts
- Study coordinator: Guillaume BEAUMATIN
- Email: guillaume.beaumatin@chu-poitiers.fr
- Phone: +33549443652
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Oxygen Inhalation Therapy Endoscopy