Comparing two breathing methods during endoscopy of the pharynx, larynx, and oesophagus
Official title: OPTIGO /Comparison of Two Ventilation Methods During Endoscopy of the Pharynx, Larynx and Oesophagus: Multicentre, Randomised, Non-inferiority Trial
Run by Poitiers University Hospital · NCT07004699 · Data updated 2026-11-12
It will test whether keeping adults breathing on their own with high-flow oxygen or using standard ventilation makes endoscopy of the throat and oesophagus safer and easier.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 610 (estimated) |
| Sponsor | Poitiers University Hospital Academic / other |
| Locations | 3 sites (La Roche-sur-Yon and 2 other locations) |
| Status | Recruiting |
| Started | July 11, 2025 |
| Main results expected | July 1, 2027 |
| Study ends | July 1, 2027 |
| Registry record updated | August 31, 2026 |
| Trial ID | NCT07004699 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who do not require supplemental oxygen and are scheduled for an exclusive endoscopy of the pharynx, larynx and oesophagus and can give informed consent.
✕Probably not a fit
Patients having combined procedures, with BMI ≥35, stage IV COPD, or known allergy to remifentanil, propofol, or lidocaine are excluded and unlikely to benefit from the tested ventilation strategies.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults scheduled for an exclusive endoscopy of the pharynx, larynx and oesophagus at CHU de Poitiers will be assigned to one of two ventilation strategies during the procedure: spontaneous ventilation supported by high-flow oxygen or conventional ventilation under general anaesthesia. The trial monitors intraoperative oxygenation, airway visibility, procedural conditions and immediate safety outcomes. Patients with combined procedures, severe obesity, or advanced COPD are excluded to reduce risk and improve comparability. Results will show whether one method provides better visibility and safety during these diagnostic or therapeutic endoscopies.
Why it matters
Potential benefit: If successful, the tested approach could improve airway visibility and oxygen safety during endoscopy and may reduce the need for more invasive ventilation for some patients.
How similar studies have gone: High-flow nasal oxygen and spontaneous ventilation have been used in airway procedures with promising oxygenation and visibility results, but direct comparative evidence remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged 18 or over. * Scheduled for upper aerodigestive tract endoscopy (pharynx, larynx, oesophagus). * ASA physical status I to IV. * No requirment for preoperative supplemental oxygen. * Informed consent signed. Exclusion Criteria: * Endoscopy combined with another procedure. * Body mass index ≥ 35 kg/m². * Severe chronic obstructive pulmonary disease (GOLD stage IV). * Allergy to one of the anaesthetic agents (remifentanil, propofol, lidocaine). * Baseline SpO2 ≤ 92% on arrival in the operating room
Where it's running
-
CHD Vendée
La Roche-sur-Yon, France Recruiting -
CHU Limoges
Limoges, France Recruiting -
CHU Poitiers
Poitiers, France Recruiting
Study contacts
- Study coordinator: Guillaume BEAUMATIN
- Email: guillaume.beaumatin@chu-poitiers.fr
- Phone: +33549443652
Similar studies
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-
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.