Comparing two approaches for treating blocked coronary arteries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness and safety of two different approaches, antegrade and retrograde, for performing percutaneous coronary interventions in patients with chronic total occlusions (CTOs) of coronary arteries. It aims to analyze clinical and anatomical differences, success rates, complication patterns, and long-term outcomes associated with each approach. By identifying independent factors that necessitate a retrograde approach, the study seeks to enhance understanding of the best practices for treating CTOs. The findings could inform clinical decision-making and improve patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged\>=19
* Patients who have a CTO lesion in at least one or more epicardial coronary artery 2.5 mm in blood vessel diameter
* Patients who have symptoms of angina or objectively proven myocardial ischemia (asymptomatic myocardial ischemia, stable or unstable angina, non - -ST-segment elevation myocardial infarction)
* Patients who voluntarily agreed to the protocol and the clinical follow-up plan (or let their representative do this), and signed the informed consent form approved by the IRB of each study institute

Exclusion Criteria:

* Patients who are pregnant or lactating or have childbearing potential Patients in whom contrast medium and heparin are contraindicated or who are hypersensitive to them
* Patients in whom aspirin, clopidogrel, ticagrelor and prasugrel, cilostazol are contraindicated
* Patients scheduled to undergo a surgery, etc. that requires discontinuance of an antiplatelet drug within 12 months after participation in the study
* Acute ST elevation myocardial infarction at the time of hospitalization
* Terminally ill patients with their life expectancy \< one year
* Patients who have serious diseases other than cardiac diseases that may affect limitation of residual life time or observation of the protocol (e.g. oxygen-independent chronic obstructive pulmonary disease, persisting hepatitis or serious hepatic insufficiency, severe renal disease, etc. Be left up to the discretion of the investigator.)

Where it's running

• Hallym University Sacred Heart Hospital
  Anyang, South Korea Recruiting
• SoonChunHyang University Hospital Bucheon
  Bucheon-si, South Korea Recruiting
• Gyeongsang National University Changwon Hospital
  Changwon, South Korea Recruiting
• Chungbuk National University Hospital
  Cheongju-si, South Korea Recruiting
• Gangwon National University Hospital
  Chuncheon, South Korea Recruiting
• Keimyung University Dongsan Medical Center
  Daegu, South Korea Recruiting

Study contacts

• Principal investigator: Seung-Whan Lee, MD — Asan Medical Center
• Study coordinator: Seung-Whan Lee, MD
• Email: seungwlee@amc.seoul.kr
• Phone: 8210-7398-9897

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using a new guidewire system to treat blocked coronary arteries

  This study is testing a new guidewire system to see if it can help doctors treat blocked coronary arteries in patients who have had these blockages for over three months.

  Recruiting at 2 sites VasoStar, LLC · Atlanta, Georgia and 1 other locations · NCT06193954

• Comparing heart procedures and medication for blocked coronary arteries

  This study is testing if a heart procedure called PCI can help people with completely blocked coronary arteries feel better and have improved heart function compared to just using medication.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT03756870

• Comparing PCI and medical therapy for chronic total occlusion in heart disease

  This study is testing whether a new heart procedure using special stents can help people with blocked arteries feel better and have fewer heart problems compared to just taking medication.

  Recruiting at 14 sites Aarhus University Hospital Skejby · Aarhus N and 26 other locations · NCT03563417

• Registry for treating chronic total occlusion of coronary arteries in Japan

  This study is gathering information from patients in Japan who have had a specific heart procedure to treat blocked arteries, to see how to improve treatment for these cases.

  Recruiting Kurashiki Central Hospital · Kurashiki · NCT01889459

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.