Comparing two anesthetic techniques for total knee replacement
Official title: Expanding the Peri-operative Surgical Home Model: ERAS TKR With a Transitional Pain Service (TeleTPS)- Continuous Adductor Canal Catheter Versus Adductor Canal Block for Total Knee Arthroplasty, a Randomized Double-blind Controlled Trial
Run by Hospital for Special Surgery, New York · NCT03747146 · Data updated 2026-11-12
This study is testing two different ways to manage pain during total knee replacement surgery to see which one helps patients recover better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 94 (estimated) |
| Sponsor | Hospital for Special Surgery, New York Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | November 16, 2018 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | April 28, 2026 |
| Trial ID | NCT03747146 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking patients aged 18 to 65 with osteoarthritis scheduled for total knee arthroplasty who live within one hour of the hospital.
✕Probably not a fit
Patients with severe comorbidities, chronic pain conditions, or those undergoing general anesthesia may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial compares two anesthetic techniques for patients undergoing total knee replacement surgery. Participants will be randomly assigned to receive either a single-shot adductor canal block or a continuous adductor canal block catheter in addition to a peri-articular injection and an IPACK block. The goal is to evaluate the effectiveness of these techniques in managing postoperative pain. The study aims to enhance recovery after surgery by optimizing pain management strategies.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management and faster recovery for patients undergoing total knee replacement.
How similar studies have gone: Other studies have shown promising results with similar anesthetic approaches, indicating potential for success in this trial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with osteoarthritis scheduled for a primary total knee arthroplasty with a participating surgeon * Planned use of regional anesthesia * Ability to follow study protocol * English speaking (secondary outcomes include questionnaires validated in English only) * Lives within one hour of the hospital * Has a smart phone Exclusion Criteria: * Hepatic or renal insufficiency * Younger than 18 years old or older than 65 years ol * Patients undergoing general anesthesia * Allergy or intolerance to one of the study medications * BMI \>40 * Diabetes * American Society of Anesthesiologists (ASA) status III or IV * Chronic gabapentin/pregabalin use (regular use for longer than 3 months) * Patients with chronic pain (from a referral to chronic pain service) or a pain catastrophizing scale (PCS \>30) * Patients with severe valgus deformity or flexion contracture * Patients unable to follow home catheter instructions and unwilling to go home with an infusing catheter * Patients who have no home caregivers in the event that a catheter is to be sent home with the patient * Patients with planned stay at rehab facility (to avoid medical device being tampered with at the rehab facility) * Non-English speakers (secondary outcomes include questionnaires validated in English only)
Where it's running
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Hospital for Special Surgery
New York, New York, United States Recruiting
Study contacts
- Principal investigator: David Kim, MD — Hospital for Special Surgery, New York
- Study coordinator: George Birch, BS
- Email: birchg@hss.edu
- Phone: 212-774-7377
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.