Comparing treatments for placenta accreta with and without internal iliac ligation
Conservative Management of Placenta Accreta Spectrum With or Without Internal Iliac Ligation: A Randomized Controlled Trial
This study is testing if a procedure called internal iliac ligation can help women with placenta accreta have safer pregnancies and keep their ability to have children in the future.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 20 Years to 35 Years |
| Sex | Female |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta) |
| Trial ID | NCT05232981 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of internal iliac ligation in patients diagnosed with placenta accreta spectrum (PAS). Conducted at Tanta University Hospital in Egypt, the study will recruit cases from the outpatient clinic and utilize ultrasound and MRI for accurate diagnosis. Participants will be randomized to receive either the ligation procedure or standard care, with careful monitoring for complications such as hemorrhage. The study is designed to assess the safety and potential benefits of this intervention in preserving fertility and reducing the need for hysterectomy.
Who should consider this trial
Good fit: Ideal candidates are women under 35 years old with a prenatal diagnosis of placenta accreta who wish to preserve their fertility.
Not a fit: Patients with high risks of intraoperative blood loss or those who have completed their family may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of severe complications during cesarean sections for patients with placenta accreta.
How similar studies have performed: While there is limited data on this specific approach, similar studies have shown promising results in managing placenta accreta with innovative surgical techniques.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age under 35 years old. 2. Prenatally diagnosed placenta accreta . 3. Planned caesarean section ≤ 37 wks . 4. ≤ previous 3 ceserian sections . 5. Placenta accretta spectrum grade 1 , 2 ,3 . 6. Patients who want to preserve their fertility. 7. Patients who refuse hysterectomy . Exclusion Criteria: 1. Cases with high risk of intraoperative blood loss as hemorrhagic disorders and thrombocytopenia . 2. Cases on anticoagulant therapy. 3. Patients who completed her family. 4. Hemodynamicaly unstable patients. 5. Finally cases who refused to get enrolled in the study.
Where this trial is running
Tanta
- Ayman Dawood — Tanta, Egypt (Recruiting)
Study contacts
- Study coordinator: Ayman Dawood, MD
- Email: ayman.dawood@med.tanta.edu.eg
- Phone: +201020972067
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.