Comparing treatments for early missed abortion
A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion
This project will see if different treatment methods and estrogen doses help people with early missed abortion recover safely and reduce complications.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 580 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | The Third Xiangya Hospital of Central South University Academic / other |
| Locations | 1 site (Changsha, Hunan) |
| Trial ID | NCT07422506 on ClinicalTrials.gov |
What this trial studies
This research collects clinical data to compare surgical versus medical management for early missed abortion and tracks reproductive outcomes. It has two parts: a retrospective analysis comparing past cases of surgery and drug treatment, and a prospective phase testing different estrogen doses combined with either surgery or medical induction. Investigators will compare treatment success rates, complication rates, and subsequent fertility outcomes using statistical analyses. The aim is to find regimens that achieve complete uterine evacuation with fewer complications and clearer guidance on estrogen dosing.
Who should consider this trial
Good fit: People aged 18–40 with imaging- and lab-confirmed early missed abortion, normal routine exam results, no need for emergency curettage, and the ability to attend follow-up are the intended participants.
Not a fit: Patients with contraindications to medical abortion or estrogen, heavy vaginal bleeding, thromboembolic disease, hormone-dependent tumors, severe organ disease, or inability to follow up are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could identify treatment approaches that lower complication rates and improve reproductive outcomes after early missed abortion.
How similar studies have performed: Previous research has compared surgical and medical management for missed abortion, but using high-dose estrogen as an adjunct is less well studied and evidence is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ①Age 18-40 years old; ②Early pregnancy missed abortion confirmed by imaging and laboratory tests; ③All indicators of routine examinations before treatment are within the normal range, and there are no serious systemic diseases; ④No indications for emergency curettage; ⑤Good compliance, follow-up observation as required (prospective study). Exclusion Criteria: * ①Contraindications to medical abortion; ②Those who are allergic to estrogen and have contraindications to the use of estrogen; ③Those who cannot be followed up according to the follow-up plan; ④Thromboembolic diseases, known or suspected history of breast cancer, hormone-dependent tumors, etc.; ⑤Vaginal bleeding exceeds the usual menstrual volume; ⑥Those with severe heart, liver and kidney diseases; ⑦Accompanied by serious internal and surgical diseases, malignant tumors or mental illnesses, and cannot cooperate.
Where this trial is running
Changsha, Hunan
- The Third Xiangya Hospital of Central South University — Changsha, Hunan, China (Recruiting)
Study contacts
- Study coordinator: Dabao Xu
- Email: forxudabao@126.com
- Phone: 13017386201
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.