Comparing treatments for early missed abortion

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research collects clinical data to compare surgical versus medical management for early missed abortion and tracks reproductive outcomes. It has two parts: a retrospective analysis comparing past cases of surgery and drug treatment, and a prospective phase testing different estrogen doses combined with either surgery or medical induction. Investigators will compare treatment success rates, complication rates, and subsequent fertility outcomes using statistical analyses. The aim is to find regimens that achieve complete uterine evacuation with fewer complications and clearer guidance on estrogen dosing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ①Age 18-40 years old; ②Early pregnancy missed abortion confirmed by imaging and laboratory tests; ③All indicators of routine examinations before treatment are within the normal range, and there are no serious systemic diseases; ④No indications for emergency curettage; ⑤Good compliance, follow-up observation as required (prospective study).

Exclusion Criteria:

* ①Contraindications to medical abortion; ②Those who are allergic to estrogen and have contraindications to the use of estrogen; ③Those who cannot be followed up according to the follow-up plan; ④Thromboembolic diseases, known or suspected history of breast cancer, hormone-dependent tumors, etc.; ⑤Vaginal bleeding exceeds the usual menstrual volume; ⑥Those with severe heart, liver and kidney diseases; ⑦Accompanied by serious internal and surgical diseases, malignant tumors or mental illnesses, and cannot cooperate.

Where it's running

• The Third Xiangya Hospital of Central South University
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Dabao Xu
• Email: forxudabao@126.com
• Phone: 13017386201

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.