Comparing treatment protocols for quality of life after thyroid surgery
Comparing the Quality of Life Associated With Empiric Calcium Repletion and Parathormone (PTH) Based Calcium Repletion for Post Thyroidectomy Hypoparathyroidism
This study is testing two different ways to manage low calcium levels after thyroid surgery to see which one helps patients feel better in their daily lives.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | CHU de Quebec-Universite Laval Academic / other |
| Locations | 1 site (Québec, Quebec) |
| Trial ID | NCT03249012 on ClinicalTrials.gov |
What this trial studies
This study compares two treatment protocols for managing post-thyroidectomy hypoparathyroidism. Patients will be randomized into two groups: one receiving calcium carbonate and calcitriol with a standardized weaning process, and the other receiving these treatments only if specific PTH levels are low. The quality of life will be assessed using the Short-Form 36 (SF-36) questionnaire before surgery and at one and four weeks post-operation. Additionally, symptoms of hypocalcemia and side effects will be monitored during the same follow-up periods.
Who should consider this trial
Good fit: Ideal candidates are individuals who have undergone total thyroidectomy or completion hemithyroidectomy.
Not a fit: Patients requiring neck dissection or those unable to complete questionnaires due to various reasons will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the quality of life for patients suffering from post-thyroidectomy hypoparathyroidism.
How similar studies have performed: While there have been studies on hypoparathyroidism management, this specific comparison of treatment protocols is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Total thyroidectomy or completion hemithyroidectomy Exclusion Criteria: * Need for neck dissection * Unable to fill in questionnaires (intellectual deficit, severe psychiatric disorder, illiterate, does not speak French or English)
Where this trial is running
Québec, Quebec
- CHU de Quebec — Québec, Quebec, Canada (Recruiting)
Study contacts
- Study coordinator: Jean-Philippe Vezina, MD, FRCSC
- Email: jean-philippe.vezina@fmed.ulaval.ca
- Phone: 418-649-0252
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.