Comparing transcutaneous and arterial CO2 monitoring during jet ventilation for percutaneous liver tumor ablation
Transcutaneous Versus Arterial Carbon Dioxide Monitoring During Jet Ventilation
This project will test whether skin-based (transcutaneous) CO2 monitors give the same readings as arterial blood CO2 in adults having jet ventilation during percutaneous liver tumor ablation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sahlgrenska University Hospital Academic / other |
| Locations | 1 site (Gothenburg) |
| Trial ID | NCT07211763 on ClinicalTrials.gov |
What this trial studies
During percutaneous radiofrequency ablation of liver tumors, high-frequency jet ventilation is used to reduce diaphragm movement but prevents standard end-tidal CO2 monitoring. At this single center, patients receive both transcutaneous CO2 monitoring and arterial blood gas sampling as part of routine care, and consenting patients will have those values collected prospectively. The collected paired measurements will be compared using repeat-measures Bland–Altman analysis to quantify agreement and any systematic differences. All patients are managed according to the usual preoperative and intraoperative protocols and participation only involves allowing use of their monitoring data for analysis.
Who should consider this trial
Good fit: Adults scheduled for percutaneous radiofrequency liver tumor ablation who require jet ventilation and can give informed consent are the intended participants.
Not a fit: Patients not receiving jet ventilation, minors, or those with conditions that make jet ventilation unsafe would not be eligible and would not benefit from this comparison.
Why it matters
Potential benefit: If transcutaneous monitoring reliably matches arterial CO2, patients could avoid some invasive blood sampling and clinicians would have a noninvasive way to track ventilation during jet ventilation.
How similar studies have performed: Prior work outside jet ventilation has shown reasonable agreement between transcutaneous CO2 and arterial CO2 in other ventilation settings, but data specifically during high-frequency jet ventilation are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients undergoing percutaneous RF liver tumour ablation requiring jet ventilation Exclusion Criteria: * disease or condition. not compatible with jet ventilation
Where this trial is running
Gothenburg
- Sahlgrenska University Hospital — Gothenburg, Sweden (Recruiting)
Study contacts
- Principal investigator: Fredrik Olsen, MD PhD — Sahlgrenska University Hospital
- Study coordinator: Fredrik Olsen, MD PhD
- Email: fredrik.olsen@vgregion.se
- Phone: +46 313428169
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.