Comparing tourniquet pressures during lower extremity surgery
Official title: Evaluation of Ischemia and Reperfusion Interval With Neuromonitorization in Tourniquet Application
Run by Istanbul University · NCT05926154 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether using different pressures for tourniquets during lower leg surgeries affects nerve function and muscle health in patients.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Istanbul University Academic / other |
| Locations | 1 site (Istanbul, Fatih-Topkapı) |
| Trial ID | NCT05926154 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals scheduled for foot and ankle surgeries without significant comorbidities.
✕Probably not a fit
Patients with a history of previous foot or ankle surgeries, diabetes, or peripheral vascular diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effects of two different tourniquet pressures on neuromonitoring and quadriceps muscle atrophy during lower extremity surgeries. Participants will be randomized into two groups receiving either limb occlusion pressure +50 mmHg or +100 mmHg. The study will assess neurophysiological effects, quadriceps tendon thickness, thigh circumference, and other parameters preoperatively and at follow-up intervals of 1 day, 1 week, and 1 month post-surgery. The goal is to determine the optimal reperfusion interval and the impact of tourniquet pressure on muscle denervation.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical outcomes and reduced muscle atrophy in patients undergoing lower extremity surgeries.
How similar studies have gone: While similar studies have explored tourniquet pressures, this specific approach to neuromonitorization and its effects on quadriceps muscle atrophy is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Operation planning in the foot and ankle area Exclusion Criteria: * Having a history of previous foot and ankle surgery, * Having a history of previous knee surgery or spinal surgery, * Diagnosis of diabetes mellitus, * Having a known diagnosis of a disease affecting the peripheral nervous system (peripheral neuropathy, previous spinal surgery, stroke, etc.), * Having a diagnosis of a disease affecting the known peripheral vascular system (Peripheral vascular disease, calcified popliteal artery, peripheral arterial bypass surgery, vasculitis, advanced chronic venous insufficiency), * Having a disease that affects the ideal tourniquet application (Chronic Lymphedema, BMI\>35, Stage 3 and above chronic renal failure, uncontrollable hypertension), * Having been diagnosed with a known coagulation disorder, * History of pulmonary embolism or deep vein thrombosis. * ASA score above 3 * Surgery time to be less than 80 minutes
Where it's running
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Department of Orthopaedics and Traumatology, Istanbul University, Istanbul, Turkey
Istanbul, Fatih-Topkapı, Turkey Recruiting
Study contacts
- Study coordinator: Ahmet Muçteba YILDIRIM, Asistant Dr
- Email: ahmet.yildirim.93@istanbul.edu.tr
- Phone: 090 534 303 8472
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.