Comparing timing for resuming blood thinners after polyp removal
Official title: Timing of Resumption of Direct Oral Anticoagulants Following Colonoscopy Polypectomy: a Prospective Randomized Non-inferiority Trial
Run by The University of Hong Kong · NCT06482333 · Data updated 2026-11-12
This study is testing whether it's safe for people on blood thinners to start taking them again right after having polyps removed during a colonoscopy, compared to waiting two days.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years and up |
| Sex | All |
| Enrollment | 194 (estimated) |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | October 3, 2024 |
| Main results expected | August 1, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | May 1, 2026 |
| Trial ID | NCT06482333 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult patients on DOACs scheduled for elective colonoscopy with polypectomy.
✕Probably not a fit
Patients with prior colonic resections, inflammatory bowel disease, or those requiring advanced polypectomy techniques will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective randomized trial aims to evaluate the safety of resuming Direct Oral Anticoagulants (DOACs) either on the same day or two days after colonoscopic polypectomy. Patients will be randomly assigned to one of two groups: one group will resume DOACs immediately after the procedure, while the other will wait for two days. The study will assess the rates of post-polypectomy bleeding in both groups to determine if early resumption is as safe as delayed resumption. All procedures will be performed by experienced endoscopists following a standardized polypectomy protocol.
Why it matters
Potential benefit: If successful, this study could help optimize anticoagulant management for patients undergoing polypectomy, reducing the risk of bleeding complications.
How similar studies have gone: While similar studies have explored anticoagulant management, this specific comparison of resumption timing after polypectomy is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- All adult patients who are taking DOACs and schedule for elective colonoscopy are potentially eligible. We only included patients who had complete colonoscopy and with polypectomy performed. Exclusion Criteria: * Previous resection of any colonic segments, * Inflammatory bowel disease or polyposis syndrome * Patient with large polyp required advanced procedure e.g. endoscopic submucosal dissection (ESD) to remove * Patients who develop immediate post-polypectomy bleeding during the procedure and requiring haemostasis will also be excluded * Patient without polypectomy * Patient without complete colonoscopy done
Where it's running
-
Queen Mary Hospital, the University of Hong Kong
Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Wai Keung Leung — The University of Hong Kong
- Study coordinator: Wai Keung Leung
- Email: waikleung@hku.hk
- Phone: +852 22553348
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.