Comparing three transthoracic needle biopsy techniques for people with suspected lung cancer
Official title: Accuracy Between Jabbing-then-suction, Suction-with-jabbing, and Suction-only Transthoracal Needle Aspiration (TTNA) Techniques in Suspected Lung Cancer Patients
Run by Gadjah Mada University · NCT07255950 · Data updated 2026-11-12
This project will test three transthoracic needle aspiration methods to see which one yields the best tumor samples in adults with suspected lung cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 54 (estimated) |
| Sponsor | Gadjah Mada University Academic / other |
| Locations | 1 site (Yogyakarta, Special Region of Yogyakarta) |
| Status | Recruiting |
| Started | July 15, 2025 |
| Main results expected | December 2025 |
| Study ends | February 2026 |
| Registry record updated | December 1, 2025 |
| Trial ID | NCT07255950 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 with a peripheral lung lesion attached to the chest wall who are scheduled for ultrasound-guided transthoracic needle biopsy are ideal candidates.
✕Probably not a fit
People with respiratory failure, on positive-pressure ventilation, severe emphysema, advanced pulmonary fibrosis, contralateral pneumonectomy, significant coagulopathy, or who refuse or cannot cooperate with biopsy are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Hospitalized adults with suspected peripheral lung cancer attached to the chest wall will undergo ultrasound-guided transthoracic needle sampling using three TTNA techniques (jabbing-then-suction, suction-with-jabbing, and suction-only) alongside a core needle biopsy as the reference standard. Procedures are done under local anesthesia in the operating room with an anesthesiologist present, and the techniques used are routine clinical procedures. Samples will be compared for quality and diagnostic accuracy, and patients will be observed for at least 24 hours for complications. The trial focuses on whether one sampling technique provides superior sample quality or diagnostic yield compared with the others and with core biopsy.
Why it matters
Potential benefit: If successful, the results could identify a simpler TTNA method that gives better tissue samples, reducing the need for repeat biopsies and speeding definitive diagnosis.
How similar studies have gone: The individual TTNA techniques are routine and widely used in practice, but direct head-to-head comparisons against each other with core needle biopsy as a reference are limited, so the question is relatively under-studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with suspected lung cancer who will undergo diagnostic testing using ultrasound-guided TTNA of the lung with cell block and core biopsy. * Patients aged 18-75 years. * The tumor is located peripherally, attached to the chest wall. Exclusion Criteria: * Patient refuses lung biopsy * Non-cooperative patient * Patient with respiratory failure, on positive pressure ventilation * Severe pulmonary emphysema * Contralateral pneumonectomy * Advanced pulmonary fibrosis * Platelet count \<100,000/mm3 and international normalized ratio (INR) \>1.4
Where it's running
-
Universitas Gadjah Mada Academic Hospital (RSA UGM)
Yogyakarta, Special Region of Yogyakarta, Indonesia Recruiting
Study contacts
- Study coordinator: dr. Roihan Mohamad Iqbal
- Email: roihan.iqbal@gmail.com
- Phone: +6285933626780
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.