Comparing three transthoracic needle biopsy techniques for people with suspected lung cancer
Accuracy Between Jabbing-then-suction, Suction-with-jabbing, and Suction-only Transthoracal Needle Aspiration (TTNA) Techniques in Suspected Lung Cancer Patients
This project will test three transthoracic needle aspiration methods to see which one yields the best tumor samples in adults with suspected lung cancer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 54 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Gadjah Mada University Academic / other |
| Locations | 1 site (Yogyakarta, Special Region of Yogyakarta) |
| Trial ID | NCT07255950 on ClinicalTrials.gov |
What this trial studies
Hospitalized adults with suspected peripheral lung cancer attached to the chest wall will undergo ultrasound-guided transthoracic needle sampling using three TTNA techniques (jabbing-then-suction, suction-with-jabbing, and suction-only) alongside a core needle biopsy as the reference standard. Procedures are done under local anesthesia in the operating room with an anesthesiologist present, and the techniques used are routine clinical procedures. Samples will be compared for quality and diagnostic accuracy, and patients will be observed for at least 24 hours for complications. The trial focuses on whether one sampling technique provides superior sample quality or diagnostic yield compared with the others and with core biopsy.
Who should consider this trial
Good fit: Adults aged 18–75 with a peripheral lung lesion attached to the chest wall who are scheduled for ultrasound-guided transthoracic needle biopsy are ideal candidates.
Not a fit: People with respiratory failure, on positive-pressure ventilation, severe emphysema, advanced pulmonary fibrosis, contralateral pneumonectomy, significant coagulopathy, or who refuse or cannot cooperate with biopsy are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could identify a simpler TTNA method that gives better tissue samples, reducing the need for repeat biopsies and speeding definitive diagnosis.
How similar studies have performed: The individual TTNA techniques are routine and widely used in practice, but direct head-to-head comparisons against each other with core needle biopsy as a reference are limited, so the question is relatively under-studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with suspected lung cancer who will undergo diagnostic testing using ultrasound-guided TTNA of the lung with cell block and core biopsy. * Patients aged 18-75 years. * The tumor is located peripherally, attached to the chest wall. Exclusion Criteria: * Patient refuses lung biopsy * Non-cooperative patient * Patient with respiratory failure, on positive pressure ventilation * Severe pulmonary emphysema * Contralateral pneumonectomy * Advanced pulmonary fibrosis * Platelet count \<100,000/mm3 and international normalized ratio (INR) \>1.4
Where this trial is running
Yogyakarta, Special Region of Yogyakarta
- Universitas Gadjah Mada Academic Hospital (RSA UGM) — Yogyakarta, Special Region of Yogyakarta, Indonesia (Recruiting)
Study contacts
- Study coordinator: dr. Roihan Mohamad Iqbal
- Email: roihan.iqbal@gmail.com
- Phone: +6285933626780
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.