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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Comparing three oral care methods for ICU patients on non-invasive ventilation

Official title: Comparison of Three Different Oral Care Methods in Terms of Oral Health in Intensive Care Patients Receiving Non-Invasive Mechanical Ventilation: A Randomized Controlled Trial

Run by Ataturk University · NCT07200297 · Data updated 2026-11-12

This study will try three oral care routines—standard chlorhexidine alone, chlorhexidine with an electric toothbrush, or chlorhexidine with a manual toothbrush—for adults on non-invasive ventilation in the ICU to see which keeps the mouth healthiest.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment60 (estimated)
SponsorAtaturk University
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Erzurum, Merkez)
StatusRecruiting
StartedSeptember 15, 2025
Main results expectedJanuary 1, 2026
Study endsApril 1, 2026
Registry record updatedOctober 1, 2025
Trial IDNCT07200297 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults in the intensive care unit who are on non-invasive mechanical ventilation, are conscious and able to communicate, have consented to participate, and are expected to remain in ICU for at least 48 hours.

Probably not a fit

Patients who are intubated, have severe oral infections or bleeding mucosal wounds, have had head/neck radiotherapy or chemotherapy, are organ transplant recipients, or have other conditions that prevent safe oral hygiene are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled experiment will enroll adult ICU patients receiving non-invasive mechanical ventilation and assign them to one of three oral care groups: standard chlorhexidine alone, chlorhexidine plus an electric toothbrush and toothpaste, or chlorhexidine plus a manual toothbrush and toothpaste. Oral health will be measured using a demographic form, an Oral Assessment Guide, saliva pH testing, and salivation measurement with Schirmer Tear Test Strips. Participants must be conscious, able to communicate, free of active infection, and expected to remain in the ICU at least 48 hours. The study compares outcomes across groups to identify which combination most effectively maintains or improves oral health in this patient population.

Why it matters

Potential benefit: If successful, the preferred oral care method could reduce oral complications and improve comfort for ICU patients on non-invasive ventilation, potentially lowering downstream infection risk and care needs.

How similar studies have gone: Related ICU oral-care studies using chlorhexidine and toothbrushing have shown mixed but sometimes promising improvements in oral outcomes, while direct comparisons of electric versus manual toothbrushes in non-invasive ventilation patients remain limited.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Must be in an intensive care unit
* Must have consented to participate in the study from themselves or their family
* Must be over 18 years of age
* Must be on a non-invasive mechanical ventilator
* Must have no known active infection.
* Must be in a stable state of consciousness and able to communicate.
* Must be expected to remain in intensive care for at least 48 hours.

Exclusion Criteria:

* Intubated patients.
* Patients with severe oral infections or bleeding mucosal wounds.
* Those receiving radiotherapy/chemotherapy to the head and neck region.
* Organ transplant patients.
* Patients without oral anatomic abnormalities or dentures.
* Those who refused to participate in the study or did not sign the consent form.
* Patients with chronic or acute health conditions that prevent oral hygiene.

Where it's running

  • Ataturk University
    Erzurum, Merkez, Turkey (Türkiye)     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.