Comparing the effects of two types of mouthwash on dental health
Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash - Randomized Clinical Trail
This study is testing if a new mouthwash with Tropolone works better than a standard mouthwash to help keep the mouths of healthy adults free from germs that cause dental problems.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT03384537 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of a mouthwash containing Tropolone compared to a standard Chlorhexidine (CHX 0.2%) mouthwash in reducing intraoral microorganisms associated with dental diseases. It is a randomized clinical trial involving healthy volunteers aged 18 to 45 who will temporarily suspend their usual oral hygiene practices. The study seeks to address the ongoing challenge of dental caries, which affects a significant portion of the adult population in the U.S. by potentially offering a more effective mouthwash option for oral health maintenance.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 18 to 45 with no significant dental issues.
Not a fit: Patients with compromised medical conditions or those who have recently used antimicrobial agents may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved mouthwash formulations that significantly reduce the risk of dental caries.
How similar studies have performed: While there have been studies on mouthwash efficacy, the specific comparison of Tropolone-containing mouthwash is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients should be between 18- 45 years of age. 2. All the volunteers participated in this study will be healthy looking with free medical history. 3. The volunteers will be asked to suspend their usual oral hygiene practice from two to four days before experiment studying. Exclusion Criteria: 1. Patients with a compromised medical condition. 2. Volunteers that receive any antimicrobial agent during at least two weeks prior to study. 3. Volunteer with fixed, removable prosthesis or orthodontics appliance. 4. Volunteers with DMF above six will be excluded.
Where this trial is running
Cairo
- Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Abdelkadir — Study Principal Investigator
- Study coordinator: Mohamed Abdelkadir, master
- Email: mohamed.awad@dentistry.cu.edu.eg
- Phone: +201117147699
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.