Comparing the effects of two types of mouthwash on dental health
Official title: Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash - Randomized Clinical Trail
Run by Cairo University · NCT03384537 · Data updated 2026-11-12
This study is testing if a new mouthwash with Tropolone works better than a standard mouthwash to help keep the mouths of healthy adults free from germs that cause dental problems.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | February 8, 2024 |
| Main results expected | October 2026 |
| Study ends | December 2026 |
| Registry record updated | March 19, 2026 |
| Trial ID | NCT03384537 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy adults aged 18 to 45 with no significant dental issues.
✕Probably not a fit
Patients with compromised medical conditions or those who have recently used antimicrobial agents may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of a mouthwash containing Tropolone compared to a standard Chlorhexidine (CHX 0.2%) mouthwash in reducing intraoral microorganisms associated with dental diseases. It is a randomized clinical trial involving healthy volunteers aged 18 to 45 who will temporarily suspend their usual oral hygiene practices. The study seeks to address the ongoing challenge of dental caries, which affects a significant portion of the adult population in the U.S. by potentially offering a more effective mouthwash option for oral health maintenance.
Why it matters
Potential benefit: If successful, this study could lead to improved mouthwash formulations that significantly reduce the risk of dental caries.
How similar studies have gone: While there have been studies on mouthwash efficacy, the specific comparison of Tropolone-containing mouthwash is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients should be between 18- 45 years of age. 2. All the volunteers participated in this study will be healthy looking with free medical history. 3. The volunteers will be asked to suspend their usual oral hygiene practice from two to four days before experiment studying. Exclusion Criteria: 1. Patients with a compromised medical condition. 2. Volunteers that receive any antimicrobial agent during at least two weeks prior to study. 3. Volunteer with fixed, removable prosthesis or orthodontics appliance. 4. Volunteers with DMF above six will be excluded.
Where it's running
-
Cairo University
Cairo, Egypt Recruiting
Study contacts
- Principal investigator: Abdelkadir — Study Principal Investigator
- Study coordinator: Mohamed Abdelkadir, master
- Email: mohamed.awad@dentistry.cu.edu.eg
- Phone: +201117147699
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.