Comparing the effects of two orthodontic treatments for jaw growth in children
Official title: Comparison of Skeletal Effects of Herbst and Invisalign MA in Growing Patients With KLass Malocclusion
Run by Université Libre de Bruxelles · NCT06409923 · Data updated 2026-11-12
This study is testing which of two orthodontic treatments helps children's jaw growth better in those with a specific bite problem.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | Any age to 15 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Université Libre de Bruxelles Academic / other |
| Locations | 2 sites (Anderlecht and 1 other locations) |
| Status | Recruiting |
| Started | February 14, 2024 |
| Main results expected | September 10, 2027 |
| Study ends | September 10, 2027 |
| Registry record updated | May 10, 2024 |
| Trial ID | NCT06409923 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children aged 9 to 15 years with Class II skeletal malocclusion and specific cervical vertebral maturation stages.
✕Probably not a fit
Patients with advanced cervical vertebral maturation (CVM > 4) or periodontal disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares the skeletal, dental, and soft tissue effects of two orthodontic treatments—Mandibular Advancement aligners and the Herbst appliance—in children with Class II malocclusion. A total of approximately 30 patients aged 9 to 15 years will be recruited from initial orthodontic consultations at ULB's Erasme Hospital. Each patient will receive either treatment, and their progress will be monitored using profile cephalometry and 3D optical scans to minimize unnecessary radiation exposure. The goal is to determine which method is more effective in stimulating mandibular growth.
Why it matters
Potential benefit: If successful, this study could provide insights into more effective orthodontic treatments for children with Class II malocclusion, potentially improving their dental and skeletal development.
How similar studies have gone: While there have been studies on orthodontic treatments for malocclusion, this specific comparison of Mandibular Advancement aligners and the Herbst appliance is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * ANB greater than 4°. * Angle Class II molar and canine relationship * cervical vertebral maturation (CVM) CVM2/CVM3 Exclusion Criteria: * CVM\> 4 * periodontal disease
Where it's running
-
Université LIbre de Bruxelles
Anderlecht, Belgium Recruiting -
UNiversité Libre de Bruxelles
Brussels, Belgium Recruiting
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.