Comparing the effects of propofol and sevoflurane anesthesia on lung cancer outcomes
Official title: To Compare the Effects of Intraoperative Use of Intravenous Anesthetics Propofol and Inhaled Anesthetics Sevoflurane on the Prognosis of Patients Undergoing Surgery for Primary Lung Tumors and the Investigation of Its Mechanism of Action.
Run by Kaohsiung Medical University Chung-Ho Memorial Hospital · NCT05663242 · Data updated 2026-11-12
This study is testing whether using propofol or sevoflurane anesthesia during lung cancer surgery can lead to better recovery and survival for patients.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Kaohsiung City) |
| Status | Recruiting |
| Started | December 27, 2022 |
| Main results expected | November 30, 2026 |
| Study ends | November 30, 2026 |
| Registry record updated | May 30, 2023 |
| Trial ID | NCT05663242 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 to 80 with early-stage lung cancer who are scheduled for elective thoracic surgery under general anesthesia.
✕Probably not a fit
Patients with mental disorders, poor liver function, or those undergoing emergency surgery or palliative treatment are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial is a two-arm, parallel-group randomized trial that aims to evaluate the impact of different anesthetic agents, propofol and sevoflurane, on the prognosis of patients undergoing video-assisted thoracoscopic surgery (VATS) for primary lung tumors. Approximately 300 volunteers with early-stage lung cancer will be enrolled and randomly assigned to receive either propofol or sevoflurane during their surgery. The study will monitor various outcomes, including progression-free survival and overall survival, as well as postoperative complications and patient performance status. Data will be collected on anesthetic dosages, surgical details, and patient demographics to assess the effectiveness of each anesthetic approach.
Why it matters
Potential benefit: If successful, this study could lead to improved survival rates and better postoperative outcomes for lung cancer patients based on the choice of anesthetic.
How similar studies have gone: Other studies have explored the effects of anesthetic agents on cancer outcomes, suggesting potential benefits, but this specific comparison is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * eighteen to eighty-year-old * ASA class I-III patients * Received elective thoracic surgery for primary lung tumors under general anesthesia Exclusion Criteria: * mental disorder * poor liver function * pregnant or lactating women * morbidly obese * allergy to any of the drugs used in this study * recurrent tumor or repeat surgery * biopsy cases * incomplete outcome-data * palliative treatment after surgery * simultaneous treatment of other malignancies * emergency surgery * presence of other malignant tumors * combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine * diagnosed as benign lung tumor, or other metastatic lung tumor
Where it's running
-
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan Recruiting
Study contacts
- Study coordinator: Hung-Te Hsu, MD
- Email: hdhsu1228@hotmail.com
- Phone: 07-3121101
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
ePRO in advanced lung cancer: emotional distress, brain metastasis, and symptom burden
This study tests how patients with advanced lung cancer—some with brain metastases—report emotional distress and symptoms over time using electronic questionnaires.
-
Urine VOC Test to Detect Lung Cancer in Never Smokers
A urine test that looks for volatile compounds is tested to see if it can help detect lung cancer in adults who have never smoked.
-
SI-B036 safety test in advanced and metastatic solid tumors
This early-phase study checks whether SI-B036 is safe and tolerable in adults with advanced or metastatic solid cancers who have had prior therapy.
-
Guaraná Supplement for Cancer-Related Fatigue in People Undergoing Treatment
This study tests whether taking guaraná capsules helps reduce cancer-related fatigue and improve quality of life in adults with breast, lung, colorectal, or gastric cancer who are actively receiving treatment.
-
ENPP1/cGAS and FAP in Solid Tumors in Vietnamese Patients
This Vietnam-based study will test ENPP1, cGAS, and FAP expression in archived tumor samples from Vietnamese adults with solid cancers using immunohistochemistry.
-
Olive oil before lung cancer surgery to see if it lowers chylothorax
This study tests whether drinking 40 mL of extra-virgin olive oil a few hours before lung cancer surgery can reduce chylothorax after tumor removal.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.