Comparing the effects of propofol and sevoflurane anesthesia on lung cancer outcomes
To Compare the Effects of Intraoperative Use of Intravenous Anesthetics Propofol and Inhaled Anesthetics Sevoflurane on the Prognosis of Patients Undergoing Surgery for Primary Lung Tumors and the Investigation of Its Mechanism of Action.
This study is testing whether using propofol or sevoflurane anesthesia during lung cancer surgery can lead to better recovery and survival for patients.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Kaohsiung City) |
| Trial ID | NCT05663242 on ClinicalTrials.gov |
What this trial studies
This clinical trial is a two-arm, parallel-group randomized trial that aims to evaluate the impact of different anesthetic agents, propofol and sevoflurane, on the prognosis of patients undergoing video-assisted thoracoscopic surgery (VATS) for primary lung tumors. Approximately 300 volunteers with early-stage lung cancer will be enrolled and randomly assigned to receive either propofol or sevoflurane during their surgery. The study will monitor various outcomes, including progression-free survival and overall survival, as well as postoperative complications and patient performance status. Data will be collected on anesthetic dosages, surgical details, and patient demographics to assess the effectiveness of each anesthetic approach.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 80 with early-stage lung cancer who are scheduled for elective thoracic surgery under general anesthesia.
Not a fit: Patients with mental disorders, poor liver function, or those undergoing emergency surgery or palliative treatment are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved survival rates and better postoperative outcomes for lung cancer patients based on the choice of anesthetic.
How similar studies have performed: Other studies have explored the effects of anesthetic agents on cancer outcomes, suggesting potential benefits, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * eighteen to eighty-year-old * ASA class I-III patients * Received elective thoracic surgery for primary lung tumors under general anesthesia Exclusion Criteria: * mental disorder * poor liver function * pregnant or lactating women * morbidly obese * allergy to any of the drugs used in this study * recurrent tumor or repeat surgery * biopsy cases * incomplete outcome-data * palliative treatment after surgery * simultaneous treatment of other malignancies * emergency surgery * presence of other malignant tumors * combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine * diagnosed as benign lung tumor, or other metastatic lung tumor
Where this trial is running
Kaohsiung City
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan (Recruiting)
Study contacts
- Study coordinator: Hung-Te Hsu, MD
- Email: hdhsu1228@hotmail.com
- Phone: 07-3121101
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.