Comparing the effects of propofol and ketamine on bleeding during nasal surgeries
The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions As an Opioid Free Anaesthesia on Surgical Field in Patients Undergoing Nasal Surgeries. a Randomized Controlled Trial
This study tests whether adding propofol or ketamine to standard medications during nasal surgeries can improve the surgery experience and recovery for patients.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Trial ID | NCT06427707 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of adding either propofol or ketamine to magnesium and lidocaine infusions during nasal surgeries. It aims to compare the quality of the surgical field, intraoperative hemodynamics, surgical and recovery times, sedation scores, and the incidence of postoperative nausea and vomiting (PONV) among patients receiving different infusion combinations. The study includes patients classified as ASA I-II who are scheduled for elective nasal surgery, while excluding those with certain health conditions that could complicate the procedure.
Who should consider this trial
Good fit: Ideal candidates for this study are patients classified as ASA I-II who are scheduled for elective nasal surgery.
Not a fit: Patients with uncontrolled hypertension, cardiac disease, or other significant health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance surgical outcomes by reducing intraoperative bleeding and improving recovery times for patients undergoing nasal surgeries.
How similar studies have performed: Other studies have shown promising results with similar approaches to managing intraoperative bleeding, suggesting potential for success in this study.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I-II, * scheduled for elective nasal surgery Exclusion Criteria: * Patients with uncontrolled hypertension. * Patients with cardiac disease. * Patients with renal, hepatic or cerebral insufficiency. * Patients with coagulopathy or receiving drugs influencing blood coagulation. * Anaemia, haemoglobinopathies or polycythemia. * Pregnancy. * Patients with known sensitivity to any of the study drug.
Where this trial is running
Cairo, Cairo Governorate
- Ain Shams University — Cairo, Cairo Governorate, Egypt (Recruiting)
Study contacts
- Study coordinator: RANIA M Hussien, MD
- Email: drrania_maamon@med.asu.edu.eg
- Phone: 01000544520
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.