Comparing the effects of autologous conditioned serum and platelet-rich plasma for TMJ disorders
Comparison of the Effectiveness of Autologous Conditioned Serum and Platelet-rich Plasma in Temporomandibular Joint Osteoarthritis; A Randomized Prospective Study
This study is testing whether two treatments made from your own blood, autologous conditioned serum and platelet-rich plasma, can help relieve pain and improve function for people with TMJ disorders like osteoarthritis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Batman University Academic / other |
| Locations | 1 site (Batman, Centre/Batman) |
| Trial ID | NCT06839326 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two treatments, autologous conditioned serum (ACS) and platelet-rich plasma (PRP), for alleviating symptoms of temporomandibular joint (TMJ) disorders, particularly osteoarthritis. Both treatments are derived from the patient's own blood and aim to improve outcomes for individuals who have not responded to conservative therapies. The study involves a minimally invasive procedure called arthrocentesis, followed by the injection of either ACS or PRP to assess their impact on pain relief and functional improvement. By comparing these two approaches, the research seeks to enhance patient care in managing TMJ disorders.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have TMJ osteoarthritis and have not found relief from conservative treatments.
Not a fit: Patients who have experienced TMJ trauma, undergone surgical procedures in the area, or have certain systemic inflammatory conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide patients with a more effective treatment option for managing TMJ disorders and improving their quality of life.
How similar studies have performed: Previous studies have shown promising results for both ACS and PRP in treating osteoarthritis, indicating that this approach has potential based on existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Over 18 years old * Previously received conservative treatment but no improvement in symptoms * Patients with TMJ osteoarthritis Exclusion Criteria: * Patients who have experienced TMJ trauma or have undergone surgical procedures in this region will be excluded from the study. * Patients with facial growth disorders, systemic inflammatory joint diseases, condylar pathologies, or signs of myalgia * Patients who are pregnant or in the lactation period
Where this trial is running
Batman, Centre/Batman
- Batman University — Batman, Centre/Batman, Turkey (Recruiting)
Study contacts
- Principal investigator: Rojdan F GÜNEŞ UYSAL, PhD — Batman University
- Study coordinator: Rojdan F GÜNEŞ UYSAL, PhD
- Email: rojdangunes@hotmail.com
- Phone: 05433796751
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.