Comparing the effectiveness of clear aligners with different attachments for tooth rotation

A Randomized Clinical Trial to Compare the Influence of Optimized Attachments, IPR and a Combination of Both Techniques on the Rotational Accuracy of Canines With Clear Aligners

Not applicable Interventional University of Florida · NCT06418984

This study is testing if using different types of attachments with clear aligners can help improve the rotation of canine teeth for people getting orthodontic treatment.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment80 (estimated)
Ages18 Years to 45 Years
SexAll
SponsorUniversity of Florida Academic / other
Locations1 site (Gainesville, Florida)
Trial IDNCT06418984 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates how optimized attachments and interproximal reduction (IPR) affect the rotational accuracy of canines when using clear aligners. Participants will be randomly assigned to one of four groups, each receiving a different treatment approach. Initial orthodontic records will be collected, followed by the delivery of aligners after five weeks. The study will conclude with the collection of final records to assess the accuracy of the treatment outcomes by comparing predicted and achieved results.

Who should consider this trial

Good fit: Ideal candidates are healthy adults over 18 with rotated canines requiring derotation and who can commit to wearing Invisalign aligners.

Not a fit: Patients with poor oral hygiene, craniofacial anomalies, or those requiring surgical intervention or extraction treatments may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve the effectiveness of clear aligners in correcting tooth rotation, leading to better orthodontic outcomes.

How similar studies have performed: While there have been studies on clear aligners, this specific approach comparing optimized attachments and IPR is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria

* Physically healthy with no relevant allergies or medical problems
* Male or female above 18 years old
* Full permanent dentition except for the third molars
* Any type of malocclusion with rotated canines that require derotation
* Good oral hygiene and absence of periodontal disease
* Malocclusion to be treated with Invisalign aligners (SmartTrack)
* Any ethnic group

Exclusion Criteria

* Orthognathic surgical cases
* An extraction treatment plan
* Poor oral hygiene
* Patients with syndromes or craniofacial anomalies.
* The use of any other orthodontic appliance than clear aligners' (Invisalign)
* Malocclusion that requires auxiliaries in the simulated plan ( buttons and elastics on the canines)

Where this trial is running

Gainesville, Florida

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Rotation of Tooth
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.