Comparing Texture and Colour Enhancement Imaging (TXI) with high-definition white-light endoscopy for finding dysplasia during IBD surveillance

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Texture and Colour Enhancement Imaging (TXI) enhances texture, brightness and colour in white-light endoscopy to make subtle tissue differences more visible. This randomised paired-design study will compare TXI to high-definition white-light endoscopy during surveillance colonoscopies in eligible IBD patients, with dysplasia detection as the key outcome. Participants will undergo colonoscopy at a single centre using both imaging approaches in a randomized sequence to compare lesion detection directly. Early observational data suggest promise, but randomized evidence for dysplasia detection in IBD is lacking.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients \>16 with inflammatory bowel disease undergoing surveillance colonoscopy.
* Patients with Crohn's (L2/L3 Montreal classification) with \>50% colonic involvement OR
* Patients with ulcerative colitis with Extensive or left sided disease (E3 or E2 Montreal classification) for at least 8 years or a diagnosis of Primary sclerosing cholangitis concomitant with IBD.

Exclusion Criteria:

* Disease duration \<8 years unless a diagnosis of PSC
* Incomplete colonoscopy
* BBPS \<6 or \<2 in any segment
* MES ≥2 or any variable of the SES-CD is ≥2 or any stenosis for \>10cm segment (above the rectum)
* Previous colorectal resection
* Thrombocytopaenia (platelet count \<50) or Coagulopathy precluding biopsy
* Anticoagulation that has not been held appropriately prior to the procedure (must be held at least the morning of the procedure).
* Pregnancy
* Unable or unwilling to consent to study participation

Where it's running

• Central Middlesex Hospital
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Jonathan Landy, Consultant Gastroenterologist
• Email: Jonathan.Landy@nhs.net
• Phone: 020 8869 544

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.