Comparing Terlipressin and Carbetocin for reducing blood loss during myomectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of intramyometrial injections of Terlipressin versus Carbetocin in reducing hemoglobin loss and blood loss during open myomectomy procedures without the use of haemostatic tourniquets. It is a prospective, double-blinded, randomized, placebo-controlled trial conducted at Wael ElBanna Clinic and the NRC site. Participants will be randomly assigned to one of three groups: Terlipressin, Carbetocin, or saline, and their medical records will be reviewed to assess outcomes. The study aims to provide evidence that could influence clinical practices in gynecology.

Why it matters

Who can join: the full rules

Inclusion Criteri

* Women aged 16-45 yearsAppropriate medical status for open surgery (Largest Myoma size from 4 cm up to 20 cm)
* Baseline hemoglobin ≥9 g/dl
* No contra-indications to the use of glyopressin or carbitocin
* Myoma-related symptoms, such as pelvic pressure or pain,menorrhagia, or infertility
* Not pregnant at the time of presentation (i.e., negative urine pregnancy test or last menstrual period within the last 4 weeks)

Exclusion Criteria

* Open myomectomy using mechanical tourniquet
* Previous myomectomy
* History of bleeding disorders
* Concurrent anticoagulation therapy
* History of Uncontrolled ischaemic heart disease
* Any pelvic abnormalities requiring concomitant surgery
* Treatment with a GnRH agonist or ulipristal acetate within three months preceding surgery
* Inability to understand and provide written informed consent

Where it's running

• Wael El Banna Clinic
  Maadi, Egypt Recruiting

Study contacts

• Study coordinator: Wael El Banna
• Email: waelelbanna@drwaelelbanna.com
• Phone: 01227760402

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Temporary Clamping of Uterine and Ovarian Vessels During Minimally Invasive Myomectomy

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• Preventing bleeding during myomectomy with misoprostol

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• Preventing adhesions after myomectomy surgery

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• Does minimally invasive fibroid removal change whether fallopian tubes are open?

  This study will test if fallopian tubes are open before and after minimally invasive fibroid removal in people having myomectomy.

  Recruiting Medstar Health Research Institute · Washington D.C., District of Columbia · NCT06988774

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.