Comparing techniques for treating severe gum recession

Modified Coronally Advanced Flap and Enamel Matrix Derivative With and Without Connective Tissue Graft Wall Technique for the Treatment of Class III and IV Gingival recessions-a Randomized Control Trial

Not applicable Interventional Krishnadevaraya College of Dental Sciences & Hospital · NCT06525285

This study is testing a new technique for treating severe gum recession to see if it works better than standard treatment for people with this condition.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment24 (estimated)
Ages18 Years to 60 Years
SexAll
SponsorKrishnadevaraya College of Dental Sciences & Hospital Academic / other
Locations1 site (Bengaluru, Karnataka)
Trial IDNCT06525285 on ClinicalTrials.gov

What this trial studies

This research evaluates the effectiveness of the connective tissue graft wall technique combined with a modified coronally advanced flap in treating Miller's class III and IV gingival recessions. The study aims to assess various clinical outcomes, including probing pocket depth reduction, clinical attachment level gain, and patient aesthetic evaluations. Participants will be randomly assigned to either the control group, which receives a standard treatment, or the study group, which receives the new technique. A total of 24 participants will be included, with follow-up assessments conducted over six months.

Who should consider this trial

Good fit: Ideal candidates are systemically healthy individuals aged 18-60 with Miller's Class III and IV gingival recession.

Not a fit: Patients with systemic conditions, untreated periodontitis, or those who have previously undergone root coverage procedures may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment options for patients suffering from severe gum recession.

How similar studies have performed: While similar techniques have been explored, this specific approach is novel and has not been extensively tested in prior studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants aged 18-60 years
* Systemically healthy individuals
* Participants with Miller's Class III and IV or Cairo's RT3 gingival recession in maxillary and mandibular anteriors.
* Participants with Nordland and Tarnow's papillary recession of either I, II or III.
* Presence of interdental PPD, CAL and recession
* Radiographic evidence of interdental bone loss
* No prior experience of root coverage procedures
* Able to achieve good oral hygiene and control gingivitis in the whole of the dentition (FMPS \< 25% and FMBS \< 25%).

Exclusion Criteria:

* Grade III mobile teeth
* Pathologically migrated teeth
* Endodontically treated teeth
* Open contacts
* Pregnancy and lactating women
* Participants with systemic conditions
* Untreated periodontitis
* Persistence of uncorrected gingival trauma from tooth brushing
* Self-reported current smoking
* Presence of medical contraindications to elective surgery

Where this trial is running

Bengaluru, Karnataka

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Gingival Recession
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.