Comparing surgical and endovascular treatments for middle cerebral artery aneurysms
Official title: Middle Cerebral Artery Aneurysm Trial: A Randomized Care Trial Comparing Surgical and Endovascular Management of MCA Aneurysm Patients
Run by University of Alberta · NCT05161377 · Data updated 2026-11-12
This study is testing whether surgery or a less invasive procedure is better for treating middle cerebral artery aneurysms in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | University of Alberta Academic / other |
| Locations | 1 site (Edmonton) |
| Status | Recruiting |
| Started | May 15, 2022 |
| Main results expected | January 1, 2036 |
| Study ends | January 1, 2038 |
| Registry record updated | March 13, 2026 |
| Trial ID | NCT05161377 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with documented MCA aneurysms, whether ruptured or unruptured, who are suitable for either surgical or endovascular treatment.
✕Probably not a fit
Patients with absolute contraindications to contrast material, AVM-associated aneurysms, or those unable to provide consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of surgical versus endovascular management for middle cerebral artery (MCA) aneurysms, which are often challenging to treat due to their unique anatomical features. The study aims to gather evidence on the best management approach for both ruptured and unruptured MCA aneurysms, as current data is limited and inconclusive. Patients aged 18 and older with documented MCA aneurysms will be evaluated for eligibility, and both treatment options will be considered based on the clinical judgment of the treating team. The trial will assess clinical outcomes and complications associated with each treatment method.
Why it matters
Potential benefit: If successful, this study could provide clearer guidance on the optimal treatment for middle cerebral artery aneurysms, potentially improving patient outcomes.
How similar studies have gone: While there have been studies on aneurysm treatments, this trial specifically addresses the unique challenges of MCA aneurysms, making it a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients at least 18 years of age * At least one documented, intradural, intracranial aneurysm anywhere on the course of the MCA vessel, ruptured or unruptured. An untreated ruptured aneurysm (with delay in diagnosis) which is suspected to have occurred more than 30 days prior to study inclusion will be considered an unruptured aneurysm * In the case of SAH, WFNS grade 4 or less * The patient and aneurysm are considered appropriate for either surgical or endovascular treatment by the treating team Exclusion Criteria: * Patients with absolute contraindications administration of contrast material (any type) * Patients with AVM-associated aneurysms * Patients or caregivers unable to provide consent * Poor grade (WFNS 5) ruptured aneurysms
Where it's running
-
University of Alberta
Edmonton, Canada Recruiting
Study contacts
- Principal investigator: Tim Darsaut — University of Alberta Faculty of Medicine and Dentistry
- Study coordinator: Sudeshna Bhattacharyna
- Email: sbhattac@ualberta.ca
- Phone: 7804990974
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.