Comparing surgical and endovascular treatments for middle cerebral artery aneurysms
Middle Cerebral Artery Aneurysm Trial: A Randomized Care Trial Comparing Surgical and Endovascular Management of MCA Aneurysm Patients
This study is testing whether surgery or a less invasive procedure is better for treating middle cerebral artery aneurysms in adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Alberta Academic / other |
| Locations | 1 site (Edmonton) |
| Trial ID | NCT05161377 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of surgical versus endovascular management for middle cerebral artery (MCA) aneurysms, which are often challenging to treat due to their unique anatomical features. The study aims to gather evidence on the best management approach for both ruptured and unruptured MCA aneurysms, as current data is limited and inconclusive. Patients aged 18 and older with documented MCA aneurysms will be evaluated for eligibility, and both treatment options will be considered based on the clinical judgment of the treating team. The trial will assess clinical outcomes and complications associated with each treatment method.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with documented MCA aneurysms, whether ruptured or unruptured, who are suitable for either surgical or endovascular treatment.
Not a fit: Patients with absolute contraindications to contrast material, AVM-associated aneurysms, or those unable to provide consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide clearer guidance on the optimal treatment for middle cerebral artery aneurysms, potentially improving patient outcomes.
How similar studies have performed: While there have been studies on aneurysm treatments, this trial specifically addresses the unique challenges of MCA aneurysms, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients at least 18 years of age * At least one documented, intradural, intracranial aneurysm anywhere on the course of the MCA vessel, ruptured or unruptured. An untreated ruptured aneurysm (with delay in diagnosis) which is suspected to have occurred more than 30 days prior to study inclusion will be considered an unruptured aneurysm * In the case of SAH, WFNS grade 4 or less * The patient and aneurysm are considered appropriate for either surgical or endovascular treatment by the treating team Exclusion Criteria: * Patients with absolute contraindications administration of contrast material (any type) * Patients with AVM-associated aneurysms * Patients or caregivers unable to provide consent * Poor grade (WFNS 5) ruptured aneurysms
Where this trial is running
Edmonton
- University of Alberta — Edmonton, Canada (Recruiting)
Study contacts
- Principal investigator: Tim Darsaut — University of Alberta Faculty of Medicine and Dentistry
- Study coordinator: Sudeshna Bhattacharyna
- Email: sbhattac@ualberta.ca
- Phone: 7804990974
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.