Comparing Sugammadex and Neostigmine for Muscle Relaxant Reversal After Lung Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the effectiveness of sugammadex sodium and neostigmine in reversing neuromuscular blockade after thoracic surgery. Patients undergoing elective lung surgery under general anesthesia will receive either sugammadex or neostigmine after the administration of rocuronium bromide. The study will monitor recovery times of neuromuscular function and extubation, providing insights into optimizing muscle relaxant use during anesthesia. Data on dosage and recovery will be meticulously recorded to evaluate the outcomes of each reversal agent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients who undergo elective lung surgery under general anesthesia and require endotracheal intubation;
2. Age\>18 years old, gender not limited;
3. American Society of Anesthesiologists ASA Level I-III;
4. Use rocuronium bromide for neuromuscular blockade;
5. The patient voluntarily participated in the trial.

Exclusion Criteria:

1. The patient explicitly refused to participate in this trial;
2. Family history of malignant hyperthermia, patients with allergies to sodium sulbactam, neostigmine ingredients and their excipients, and patients with allergies to drugs used during general anesthesia;
3. Patients with tracheal malformations or suspected difficult airways, coagulation dysfunction, severe liver and kidney dysfunction, and severe lung disease;
4. Patients who are not extubated and sent to the ward or ICU after surgery;
5. The researchers believe that patients with any other unfavorable factors to participate in this trial.

Where it's running

• The Fourth Affiliated Hospital of Zhejiang University School of Medicine
  Yiwu, Zhejiang, China Recruiting

Study contacts

• Principal investigator: JianHong Xu — The Fourth Affiliated Hospital of Zhejiang University School of Medicine
• Study coordinator: JianHong Xu
• Email: xujh1969@163.com
• Phone: 86-18867961109

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.