Comparing Sugammadex and Neostigmine for Lung Function in Abdominal Surgery
Effects of Sugammadex and Conventional Reversal on Lung Function in Laparoscopic Abdominal Surgery
NA · Universiti Sains Malaysia · NCT06210165
This study is testing whether using Sugammadex instead of Neostigmine after abdominal surgery can help improve lung function and recovery for patients.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Universiti Sains Malaysia (other) |
| Locations | 1 site (Kubang Kerian, Kelantan) |
| Trial ID | NCT06210165 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the differences in lung function parameters, specifically Forced Vital Capacity (FVC), between the use of Sugammadex and conventional reversal agents like Neostigmine in patients undergoing laparoscopic abdominal surgery. Participants will undergo baseline spirometry and lung ultrasound before surgery, receive either Sugammadex or Neostigmine after the procedure, and repeat spirometry assessments postoperatively. The study seeks to determine the impact of these reversal agents on pulmonary function, atelectasis size, and length of hospital stay.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with appendicitis or cholelithiasis who are planned for laparoscopic surgery under general anesthesia and classified as ASA I-III.
Not a fit: Patients with unstable hemodynamic status, significant lung diseases, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved postoperative lung function and reduced complications for patients undergoing laparoscopic surgery.
How similar studies have performed: Previous studies have shown varying results regarding the use of Sugammadex compared to Neostigmine, but specific research on postoperative pulmonary function remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed / suspected: appendicitis or cholelithiasis * Planned for laparoscopic operation under general anaesthesia * ASA I-III Exclusion Criteria: 1. Unstable haemodynamic status 2. Patient refusal to participate 3. Altered mental status, cognitive function or mental disorder 4. Admission to postoperative care unit (PACU) under mechanical ventilation 5. Hypersensitivity to any of the drugs 6. Acute or chronic lung diseases 7. Neuromuscular disorders 8. Myocardial infarction or coronary occlusion three months prior surgery 9. Obesity BMI more or equal 30 10. Intubation prior operating room arrival 11. Pregnancy 12. Converted to open surgery
Where this trial is running
Kubang Kerian, Kelantan
- University of Science Malaysia Hospital — Kubang Kerian, Kelantan, Malaysia (RECRUITING)
Study contacts
- Principal investigator: NIK MUHAMMAD 'AIZAT 'ADROS, MBBS — Hospital Universiti Sains Malaysia
- Study coordinator: NIK MUHAMMAD 'AIZAT 'ADROS, MBBS
- Email: aizatadros@gmail.com
- Phone: +60145333560
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Atelectasis, Postoperative, Pulmonary Function, Newborn, Abnormal