Comparing sufentanil and remifentanil for pain management after laparoscopic gastrectomy
The Effects of Sufentanil-remimazolam vs. Remifentanil-remimazolam Total Intravenous Anesthesia on Postoperative Pain in Laparoscopic-assisted Gastrectomy - A Randomized, Controlled Study-
This study is testing which combination of anesthesia works better for managing pain after laparoscopic gastrectomy surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 66 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Yonsei University Academic / other |
| Locations | 1 site (Seoul) |
| Trial ID | NCT05785234 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two different total intravenous anesthesia regimens—sufentanil combined with remimazolam and remifentanil combined with remimazolam—on postoperative pain in patients undergoing laparoscopic gastrectomy. The goal is to determine which combination results in better pain control after surgery. Participants will be monitored for pain levels and recovery outcomes following their procedures.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20 years or older scheduled for laparoscopic-assisted gastrectomy with ASA physical status I to III.
Not a fit: Patients with severe comorbid conditions or those undergoing emergency operations may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing laparoscopic gastrectomy.
How similar studies have performed: Previous studies have shown varying success with different anesthesia combinations, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 20years or older 2. Scheduled for laparoscopic-assisted gastrectomy 3. American Society of Anesthesiologists(ASA) physical status I and III Exclusion Criteria: 1. Emergency operation 2. Patients with a history of severe hypersensitivity reaction to dextran 40 3. Patients who cannot use patient controlled analgesia(PCA) 4. Patients with morbid obesity \[body mass index (BMI) \>35 kg/m2\] 5. Patients with history of uncontrolled hypertension (diastolic BP \>110mmHg) or DM 6. Patients with history of heart failure (unstable angina, congestive heart failure) 7. Patients with history of liver failure, renal failure, allergic to medicine 8. Patients with history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia) 9. Patients with history of uncontrolled psychiatric disease (PTSD, anxiety, depression) 10. Patients with obstructive sleep apnea 11. Patients who cannot read the consent form (examples: Illiterate, foreigner) 12. Patients who withdraw the consent
Where this trial is running
Seoul
- Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine — Seoul, Korea, Republic of (Recruiting)
Study contacts
- Principal investigator: Sun Joon Bai, MD, PhD — Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine
- Study coordinator: Sun Joon Bai, MD, PhD
- Email: SJBAE@yuhs.ac
- Phone: 82-2-2228-4438
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.