Comparing stress response and intubation time with video versus direct laryngoscopes
Comparison of the Efficacy of Non-channelled Video Laryngoscopy Versus Direct Laryngoscopy in Terms of Stress Response and Intubation Time: a Single-blinded Randomized Controlled Trial
This trial will test whether using a video laryngoscope instead of a direct laryngoscope gives steadier blood pressure and heart rate after intubation and changes how long intubation takes in adults having elective surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 124 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Sindh Institute of Urology and Transplantation Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Trial ID | NCT07510542 on ClinicalTrials.gov |
What this trial studies
This is a single-blind, randomized comparison of video laryngoscopy (VL) versus direct laryngoscopy (DL) in adults undergoing elective surgery that requires endotracheal intubation. Participants (ASA I–II, age 18–60, BMI <30, Mallampati I–II) are randomly assigned to VL or DL and receive the same anesthesia protocol with standard monitoring (NIBP, ECG, SpO2). Hemodynamic measurements are recorded before induction, at one and three minutes after induction/ventilation, and at one, three, and five minutes after intubation, and the time required to intubate is recorded. The trial is conducted at the Sindh Institute of Urology and Transplantation in Karachi, Pakistan.
Who should consider this trial
Good fit: Adults 18–60 years old who are ASA I or II, non-hypertensive, hemodynamically stable, BMI <30, Mallampati I–II, with interincisor gap >3 cm, scheduled for elective non-airway surgery, and able to give informed consent.
Not a fit: Patients with hypertension or ischemic heart disease, ASA III–V, airway abnormalities, prior head/neck/airway surgery, emergency procedures, pregnancy, or hemodynamic instability are excluded and unlikely to benefit from this comparison.
Why it matters
Potential benefit: If successful, using a video laryngoscope could reduce blood pressure and heart rate spikes after intubation and/or shorten intubation time, improving safety during anesthesia.
How similar studies have performed: Previous studies show video laryngoscopes often improve glottic view and ease of intubation, with mixed but sometimes favorable effects on hemodynamic responses compared with direct laryngoscopy.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I \& II * Age 18-60 years. * Preoperatively nonhypertensive and hemodynamically stable patients * Patients scheduled for elective procedures not involving airway surgeries * Patients with informed consent * Mallampati score I and II * Interincisor gap \> 3 cms * BMI less than 30 kg/m² Exclusion Criteria * Patient refusal * ASA III, IV \& V * Hemodynamically unstable patients * Patients with Hypertension and Ischemic Heart Disease (whether controlled or uncontrolled) * Airway abnormalities, including congenital airway malformations \& maxillofacial abnormalities * Head, neck or any facial traumas or history of prior head, neck or airway surgeries * Emergency procedures * Pregnancy
Where this trial is running
Karachi, Sindh
- Sindh Institute of Urology and Transplantation — Karachi, Sindh, Pakistan (Recruiting)
Study contacts
- Principal investigator: Syed M Abbas — Sindh Institute of Urology and Transplantation
- Study coordinator: Syed M Abbas, FCPS
- Email: smabbas1969@gmail.com
- Phone: 02199215718
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.