Comparing stent retriever and contact aspiration for treating acute stroke

Stent Retriever Versus Contact Aspiration in Irregular Occlusion Phenotype, a Novel Approach in the Endovascular Treatment of Acute Ischemic Stroke: the STRIPE Randomized Trial.

This study is testing which of two techniques for removing blood clots, stent retriever or contact aspiration, works better for people having an acute stroke with a specific type of blockage.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 356 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Hopital Foch (Academic / other)
• Locations: 9 sites (Bordeaux and 8 other locations)
• Trial ID: NCT05595876 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness of two techniques, stent retriever thrombectomy and contact aspiration thrombectomy, in patients with acute stroke who exhibit a specific clinico-neuroradiological mismatch pattern. The study aims to determine which method leads to better recanalization outcomes and overall clinical prognosis. Patients eligible for the trial must have a certain type of occlusion in the middle cerebral artery and meet specific imaging criteria. Statistical analyses will be conducted by the Biostatistics Department of the University of Lille to ensure robust evaluation of the results.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older with M1-Middle Cerebral Artery occlusions who are eligible for mechanical thrombectomy.

Not a fit: Patients with isolated M2 occlusions or severe comorbidities that would prevent improvement are unlikely to benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve treatment outcomes for patients suffering from acute strokes by identifying the most effective thrombectomy technique.

How similar studies have performed: Previous studies, such as the ASTER Trial, have shown comparable results between stent-retrievers and contact aspiration, indicating that this approach is grounded in existing research.

Eligibility criteria

Inclusion Criteria:

* Age ≥ 18 years
* M1-Middle Cerebral Artery occlusion
* Eligible for mechanical thrombectomy: groin puncture performed within 24 hours from the first symptoms or from the last time the patient was seen normal.
* Presence of a mismatch on Magnetic resonance imaging MRI or CT (computed tomography) scan
* Baseline mRS \<2
* Irregular occlusion phenotype on the first angiographic run
* Informed consent obtained from the patients/his proxy or following an emergency procedure
* Being covered by a national health insurance

Exclusion Criteria:

* Isolated M2 occlusions
* Clinical history, past imaging or clinical judgment suggesting underlying intracranial stenosis
* Severe contrast medium allergy or absolute contraindication to use of iodinated products
* Patients with severe or fatal comorbidities that will likely prevent improvement or follow-up, or that will render the procedure unlikely to benefit the patient
* Angiographic evidence of carotid dissection or tandem cervical occlusion or stenosis requiring treatment
* Pregnancy (urine or serum beta HCG test for women of child-bearing potential)
* Patient benefiting from a legal protection (guardianship or curatorship)
* Being deprived of liberty

Where this trial is running

Bordeaux and 8 other locations

• Chu Bordeaux — Bordeaux, France (Not_yet_recruiting)
• CHU Montpellier — Montpellier, France (Not_yet_recruiting)
• Chru Nancy — Nancy, France (Recruiting)
• Chu Nantes — Nantes, France (Recruiting)
• APHP - Pitié Salpêtrière — Paris, France (Recruiting)
• Fondation Adolphe de Rothschild — Paris, France (Recruiting)
• CHU de Reims — Reims, France (Recruiting)
• Hôpital FOCH — Suresnes, France (Recruiting)
• CHU de Tours — Tours, France (Recruiting)

Study contacts

• Principal investigator: Arturo CONSOLI — Foch Hospital
• Study coordinator: Marthe MAHI

Conditions Stroke, Acute