Comparing standard once-weekly versus accelerated twice-weekly Ponseti casting for club foot
Official title: Comparison of Radiological Outcome of Conventional vs Accelerated Ponseti Casting Technique for Treatment of Club Foot: Randomized Controlled Trial
Run by Khyber Medical University Peshawar · NCT07554092 · Data updated 2026-11-12
This test will see if doing Ponseti casts twice a week instead of once helps correct club foot in babies younger than six months.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 1 Day to 5 Months |
| Sex | All |
| Enrollment | 144 (estimated) |
| Sponsor | Khyber Medical University Peshawar Academic / other |
| Locations | 1 site (Peshawar, KPK) |
| Status | Recruiting |
| Started | February 1, 2026 |
| Main results expected | October 30, 2026 |
| Study ends | November 25, 2026 |
| Registry record updated | April 28, 2026 |
| Trial ID | NCT07554092 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Babies younger than six months with untreated idiopathic club foot who can attend scheduled clinic visits are ideal candidates.
✕Probably not a fit
Infants with syndromic or previously treated club foot, other major congenital anomalies, or those unable to complete follow-up are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized open-label trial at Khyber Teaching Hospital will assign infants under six months with idiopathic club foot to either standard once-weekly Ponseti casting or an accelerated twice-weekly schedule. All other components of the Ponseti method (manipulation, tenotomy when needed, final cast, and foot abduction orthosis) are identical between groups. The primary outcome is radiological correction measured by the lateral talocalcaneal angle ≥35° on standardized X-rays six weeks after brace fitting, with secondary radiographic indices and adverse events recorded. An outcome assessor is blinded to allocation and analysis will use intention-to-treat methods.
Why it matters
Potential benefit: If successful, the accelerated schedule could shorten treatment time and reduce the burden of clinic visits while achieving equivalent correction.
How similar studies have gone: Other randomized and observational reports of accelerated Ponseti casting have shown similar short-term radiologic and clinical outcomes to standard weekly casting, though long-term recurrence data remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: -Both gender with idiopathic club foot with age less than 6 months Exclusion Criteria: * Syndromic club foot (e.g., associated with arthrogryposis, myelomeningocele, or other genetic syndromes) * Previous treatment for club foot (either serial casting or surgical intervention) * Any other significant congenital anomaly or medical condition that, in the opinion of the investigator, would interfere with treatment or follow-up
Where it's running
-
Khyber Teaching Hospital
Peshawar, Kpk, Pakistan Recruiting
Study contacts
- Principal investigator: Sikandar Hayat, MBBS, FCPS (Orthopedic Surgery — Khyber Medical University Peshawar
- Study coordinator: Sikandar Hayat, MBBS, FCPS (Orthopedic Surgery
- Email: drsikandar68@gmail.com
- Phone: 03329474849
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.