Comparing standard and high frame rate ultrasound for heart disease assessment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of high frame rate ultrasound imaging compared to standard ultrasound imaging in patients with coronary artery disease or those at low risk for heart disease. Participants will undergo imaging with two different ultrasound systems, capturing both standard and high frame rate images before and after the administration of a contrast agent and during pharmacological stress. The goal is to determine if high frame rate ultrasound provides additional diagnostic information that could improve heart disease assessment.

Why it matters

Who can join: the full rules

Inclusion criteria Either

* Ability to give informed consent
* age ≥18years and
* confirmed inducible wall motion / perfusion abnormality on previous stress echocardiogram
* known coronary artery disease - defined by presence of flow-limiting coronary stenosis(\>70% diameter stenosis) on coronary angiography.

OR

• patient who has been assessed as at low risk of having coronary heart disease

Exclusion Criteria:

* Inability to undertake pharmacological stress, ie previously known intolerance to dipyridamole;
* Moderate or Severe aortic or mitral regurgitation or severe mitral stenosis;
* Significant pulmonary disease like severe COPD or pulmonary fibrosis;
* Atrial fibrillation;
* Inability to provide informed consent;
* Pregnancy and lactation;
* Known allergy to Sonovue
* Patients with second and third degree heart block, unless they have a pacemaker fitted
* Systolic BP \< 90
* Known Myasthenia Gravis
* Bronchial asthma

Where it's running

• London North West University Healthcare NHS Trust
  Harrow, Middx, United Kingdom Recruiting

Study contacts

• Principal investigator: Roxy Senior, MD — London North West University Healthcare Nhs Trust
• Study coordinator: Emma Howard, MSc
• Email: emma.howard16@nhs.net
• Phone: +442088692547

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.