Comparing sound stimulation effects on tinnitus relief
The Effect of Different Sound Stimulation on The Residual Inhibition of Tinnitus
This study is testing whether different types of sound therapy can help people with tinnitus feel less bothered by their symptoms.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Eye & ENT Hospital of Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT06646302 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate how different types of sound stimulation affect the residual inhibition of tinnitus in patients. Participants will undergo a cross-over intervention involving low frequency burst sound stimulation and tinnitus frequency-centered narrowband noise stimulation. The study will measure subjective changes in tinnitus loudness and explore the underlying neurophysiological mechanisms using EEG and fNIRS. The goal is to determine which sound stimulation method is more effective for tinnitus relief.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 70 with subjective tinnitus of the same pitch in one or both ears.
Not a fit: Patients with vascular pulsatile tinnitus, different tones in bilateral tinnitus, or significant health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective sound therapy option for tinnitus patients.
How similar studies have performed: While the concept of sound stimulation for tinnitus is established, the specific comparison of these two methods is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults aged between 18 and 70 years old. 2. Subjective tinnitus. 3. Unilateral tinnitus or bilateral tinnitus of the same pitch. 4. Can communicate in Mandarin or with the help of an agent. 5. 50 dB HL or less on the average pure tone threshold (0.5, 1, 2kHz) of the worse ear. 6. Subjects or their legal representatives can understand the purpose of the study, voluntarily participate and can cooperate in completing the experiment according to the instructions, and sign the informed consent form. Exclusion Criteria: 1. Vascular pulsatile tinnitus or objective tinnitus. 2. Bilateral tinnitus with different tones. 3. Patients with significant health problems that interfere with or prevent participation in the experiment or cooperation with follow-up visits. 4. Patients with severe auditory hypersensitivity and psychiatric disorders such as severe anxiety and depression; 5. Currently participating in other research programs that may affect tinnitus. 6. Patients who, in the opinion of the investigator, are not suitable for participation in this clinical trial.
Where this trial is running
Shanghai, Shanghai
- Eye & ENT Hospital of Fudan University — Shanghai, Shanghai, China (Recruiting)
Study contacts
- Principal investigator: Huawei Li, PhD — Eye and ENT Hospital of Fudan University
- Study coordinator: Dongmei Tang, PhD
- Email: tang.dongm@163.com
- Phone: 13023299189
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.