Comparing slide tracheoplasty and tracheal resection with anastomosis for acquired tracheal stenosis
Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis
This comparison will test whether slide tracheoplasty or tracheal resection with anastomosis works better to relieve airway narrowing in people with acquired high-grade tracheal or subglottic stenosis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Sex | All |
| Sponsor | Mansoura University Hospital Academic / other |
| Locations | 1 site (Al Mansurah) |
| Trial ID | NCT06917222 on ClinicalTrials.gov |
What this trial studies
This interventional surgical comparison enrolls patients with symptomatic acquired high-grade (grade III–IV) tracheal or subglottic stenosis, and selected high-grade II cases after failed endoscopic therapy. Participants will undergo either slide tracheoplasty or tracheal resection with primary anastomosis according to the protocol and surgical judgment. Investigators will follow patients for outcomes such as airway patency, respiratory symptoms, perioperative complications, need for reintervention, and recovery over a planned follow-up period. The goal is to directly compare the safety and effectiveness of the two established surgical approaches for acquired tracheal narrowing.
Who should consider this trial
Good fit: People of any age with symptomatic acquired grade III–IV tracheal or subglottic stenosis, or symptomatic high-grade II after failed endoscopic treatments, who are medically fit and deemed feasible for surgery are ideal candidates.
Not a fit: Patients with congenital or malignant stenosis, those with severe comorbidities that contraindicate surgery, or people with lower-grade stenosis who respond to endoscopic treatment are unlikely to benefit from this surgical comparison.
Why it matters
Potential benefit: If successful, the comparison could identify which surgical technique provides better long-term airway patency and fewer complications, helping surgeons choose the best operation for similar patients.
How similar studies have performed: Both techniques have established success in their usual contexts—slide tracheoplasty is widely used for long-segment stenosis (often in pediatrics) and resection–anastomosis is standard for short-segment adult stenoses—although direct head-to-head comparisons are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients with grade III, IV acquired tracheal stenosis (e.g., due to trauma, prolonged intubation) regardless their age or sex. * Patient with symptomatic high grade II acquired laryngotracheal stenosis after failure of endoscopic interventions. * Clinical indications for surgical intervention (Symptoms of airway obstruction). * Feasible for surgical intervention. Exclusion Criteria: * congenital tracheal stenosis * Malignant stenosis. * Severe comorbidities that contraindicate the surgery. * Patients refusing to sign the consent.
Where this trial is running
Al Mansurah
- Eslam Hamed — Al Mansurah, Egypt (Recruiting)
Study contacts
- Study coordinator: Eslam Hamed Abdou, Assistant lecturer
- Email: eslamhamed@mans.edu.eg
- Phone: +201015566532
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.