Comparing single-fraction palliative radiotherapy to standard multi-fraction radiation
Advanced Techniques For Single-fraction Palliative Radiotherapy Versus Standard Multi Fraction Radiation
This study is testing if a single high-dose radiation treatment can help people with advanced cancer feel better for longer compared to the usual multiple smaller doses.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Sex | All |
| Sponsor | Royal North Shore Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Saint Leonards, New South Wales) |
| Trial ID | NCT04649125 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate whether a single fraction of escalated dose palliative radiotherapy can provide longer-lasting benefits compared to the standard multi-fraction approach for patients with metastatic cancer. The primary goal is to assess the percentage of patients who experience significant symptom relief and do not redevelop symptoms within 12 months post-treatment. The study focuses on patients who are typically unwell due to advanced disease and aims to optimize treatment by minimizing the number of sessions while maximizing quality of life. By exploring hypofractionated radiation, the study seeks to enhance local control and reduce the need for retreatment.
Who should consider this trial
Good fit: Ideal candidates are patients with metastatic cancer who are recommended for 5-10 fractions of palliative radiation.
Not a fit: Patients who are recommended for single fraction palliative radiation may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved symptom control and quality of life for patients undergoing palliative care.
How similar studies have performed: Previous studies have shown promise with similar hypofractionated approaches, indicating potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Metastatic cancer * Recommended for 5-10 fractions palliative radiation * Patients with spinal cord compression are eligible for enrolment Exclusion Criteria: * Unwilling or unable to give informed consent * Patients who are recommended for single fraction palliative radiation
Where this trial is running
Saint Leonards, New South Wales
- Royal North Shore Hospital — Saint Leonards, New South Wales, Australia (Recruiting)
Study contacts
- Principal investigator: Thomas Eade — Northern Sydney Cancer Centre, Royal North Shore Hospital
- Study coordinator: Carol Kwong, RN
- Email: carolyn.kwong@health.nsw.gov.au
- Phone: +61294631339
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.