Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 18 and up

Comparing short stitch and traditional suture techniques after liver surgery

Official title: Incisional Hernia Prevention After Open Hepatectomy by Small Tissue Bite Fascial Closure: A Randomized Clinical Trial

Run by M.D. Anderson Cancer Center · NCT04982653 · Data updated 2026-11-12

This study is testing whether a new short stitch method for closing the abdomen after liver surgery can help prevent hernias better than the traditional suture technique.

Quick facts

PhasePhase 2
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment140 (estimated)
SponsorM.D. Anderson Cancer Center
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Houston, Texas)
StatusRecruiting
StartedJanuary 4, 2022
Main results expectedFebruary 2, 2027
Study endsFebruary 2, 2027
Registry record updatedMay 26, 2026
Trial IDNCT04982653 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older who are scheduled for elective hepatectomy due to malignant liver conditions.

Probably not a fit

Patients with pre-existing abdominal hernias or a history of mesh placement at prior surgeries may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of two surgical closure techniques, short stitch suture and traditional suture, in preventing incisional hernias following liver tumor surgeries. The primary objective is to determine if the small bites abdominal wall closure reduces the risk of hernia development compared to the conventional method. Secondary objectives include assessing short-term outcomes, hernia rates in different patient subgroups, and the impact on quality of life post-surgery. Patients will be randomized into two groups and followed up for a year to monitor outcomes.

Why it matters

Potential benefit: If successful, this study could significantly reduce the incidence of incisional hernias in patients undergoing liver surgery.

How similar studies have gone: While this approach is being tested in this specific context, similar studies have shown promising results in other surgical fields with different closure techniques.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients undergoing hepatectomy for malignant diagnosis (primary or secondary) from 5/1/2021 through 11/1/2024 will be eligible for inclusion in this study
* Elective surgery
* Age \>= 18
* Planned midline laparotomy incision or inverted-L incision

Exclusion Criteria:

* Pre-existing abdominal hernia
* History of mesh placement at prior laparotomy
* Pregnant women

Where it's running

  • M D Anderson Cancer Center
    Houston, Texas, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.