Comparing short sprint cycling vs moderate continuous cycling to lower blood pressure in people with hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial will enroll adults 30–59 years with diagnosed hypertension and no high cardiovascular risk, randomizing them after a two-week familiarization to either low-volume Sprint Interval Training (SIT) or Moderate-Intensity Continuous Training (MICT). Interventions last 12 weeks with three supervised cycling sessions per week; SIT sessions use 2–4 maximal 20–30 second sprints with recovery (≤15 minutes total) while MICT sessions use 15–30 minutes at 50–70% VO₂max. The primary outcome is change in 24-hour ambulatory systolic blood pressure measured after 12 weeks, with secondary outcomes including diastolic/daytime/nighttime BP, body composition, metabolic profile, VO₂max, hemodynamic measures, handgrip strength, and serum myokines (IL-6 and α-CGRP). All visits and supervised sessions are conducted at the Cardio-Metabolic Disease Unit of Hospital Interzonal General de Agudos San Martín in La Plata, Argentina.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of both sexes between 30-59 years of age who meet the definition of hypertension.

Hypertension will be defined as:

1. Those patients who report a history of hypertension and are under pharmacological treatment for it (Angiotensin Converting Enzyme Inhibitors/Angiotensin II Receptor Antagonists/Calcium Channel Blockers/Thiazide Diuretics/Beta Blockers) at the time of the evaluation.

   OR
2. Patients who report a history of hypertension during the evaluation and who, without pharmacological treatment, have average levels ≥140/90 mmHg will also be considered hypertensive.

Exclusion Criteria:

* Extreme body mass index (BMI) \<18.5 and ≥35.
* Patients with office blood pressure readings ≥160/100 mmHg.
* Patients with high cardiovascular risk conditions such as type II diabetes, chronic kidney disease (\<60 milliseconds), history of cerebrovascular disease, coronary artery disease, peripheral arterial disease, or heart failure (Framingham Criteria clinical diagnosis).
* Pregnant or postpartum women up to 3 months old.
* Patients with psychophysical limitations that make exercise difficult.
* Patients with a history of active malignant neoplastic disease under treatment.

Elimination Criteria

-Patients whose pharmacological treatment is initiated or modified during the follow-up after 3 months.

Where it's running

• Hospital Interzonal General San Martin La Plata
  La Plata, Buenos Aires, Argentina Recruiting

Study contacts

• Principal investigator: Walter Espeche — Hospital Interzonal General San Martin
• Study coordinator: Julian Minetto, Physican
• Email: jjminetto@hotmail.com
• Phone: +542214835429

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Guiding Optimal Blood Pressure in Peritoneal Dialysis

  This pilot tests whether aiming for a lower systolic blood pressure target (<120 mmHg) is feasible and practical for adults with end-stage kidney disease on peritoneal dialysis, compared to a <140 mmHg target.

  Recruiting at 2 sites University of California, San Francisco · San Francisco, California and 2 other locations · NCT07910773

• New virtual care pathway for older adults with chronic diseases

  A teleconsultation-based care pathway for adults 60+ with hypertension, diabetes, or dyslipidemia to see if it’s feasible and cost-saving in Malaysian primary care compared with usual clinic visits.

  Recruiting National University of Malaysia · Kuala Lumpur · NCT07843238

• Isometric Handgrip Exercise to Lower Blood Pressure in Pregnant Women

  This study tests whether doing isometric handgrip exercises can help lower blood pressure in pregnant women, including those with chronic hypertension.

  Recruiting University of Poitiers · Poitiers · NCT07607795

• Investigating microcirculation with non-invasive devices in adults with or at risk for CKD

  This study tests two non-invasive devices (HEMI and SPG-NINOX) to see how small blood vessels behave in adults with or at risk for chronic kidney disease, hypertension, or type 2 diabetes.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT07604922

• Mobile home BP monitoring with coaching after high blood pressure from pregnancy

  This program tests whether a home blood pressure monitoring system plus virtual coaching can help midlife women, 10–20 years after a hypertensive pregnancy, manage high blood pressure better than usual care.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07599579

• Low energy availability and high blood pressure in Division I HBCU athletes

  This project will test whether not eating enough for heavy training (low energy availability) is linked to higher blood pressure and stiffer arteries in Division I HBCU athletes ages 18–25.

  Recruiting North Carolina Agriculture & Technical State University · Greensboro, North Carolina · NCT07583940

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.