Comparing short and standard antibiotic courses for leg cellulitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate whether a 5-day course of oral flucloxacillin is as effective as the standard 7-day course for treating cellulitis of the leg in adults. Participants will be randomly assigned to receive either the shorter or longer antibiotic treatment while also receiving usual care. The study will assess pain levels over a period of days 6-14 post-treatment, as well as the cost implications of the different treatment durations. Participants will complete daily questionnaires to share their experiences and symptoms during the trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Must be aged 18 years or older
* Currently showing symptoms of cellulitis (such as pain, tenderness, redness, other change in skin color, warmth to touch) in one leg for 10 days or less
* Pain rated as 3/10 or higher on a numerical rating scale (0-10) at baseline assessment
* Be willing to be randomized to either trial arm (5-day or 7-day treatment)
* Able to complete trial procedures in the English language.

Exclusion Criteria:

* Have penicillin allergy
* Have bilateral cellulitis
* Have had antibiotics for cellulitis within the past month
* Have post-operative cellulitis (within 30 days of operative procedures on the same leg)
* Have cellulitis resulting from human/animal bite injury
* Have Cellulitis associated with chronic (\>6 weeks) leg ulceration
* Require immediate hospital admission or out-patient intravenous antibiotic therapy

Where it's running

• Royal South Hants Hospital
  Southampton, United Kingdom Recruiting

Study contacts

• Study coordinator: Sophie Varkonyi-Clifford
• Email: coat@soton.ac.uk
• Phone: 0 23 8059 1532

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.