Comparing sedation protocols for ICU patients with severe pneumonia
The Application of Different Sedation Protocols in ICU Patients With Severe Pneumonia
This study looks at how different sedation methods affect the time patients with severe pneumonia spend on breathing machines in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Xiangya Hospital of Central South University Academic / other |
| Locations | 1 site (Changsha, Hunan) |
| Trial ID | NCT06514781 on ClinicalTrials.gov |
What this trial studies
This observational study collects data from 600 patients with severe pneumonia to compare the duration of mechanical ventilation under different sedation regimens. Conducted at Xiangya Hospital, Central South University, it evaluates sedation success rates, hemodynamic changes, and clinical outcomes. Patients aged 18 and older who are receiving mechanical ventilation and sedation treatment are included, while those with allergies to sedatives or who are transferred during treatment are excluded. The study aims to provide insights into the effectiveness of various sedation protocols in real-world ICU settings.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with severe pneumonia who require mechanical ventilation and sedation.
Not a fit: Patients with allergies to routine sedative or analgesic medications or those who are transferred to another hospital may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve sedation practices and clinical outcomes for patients with severe pneumonia requiring mechanical ventilation.
How similar studies have performed: Other studies have shown varying success with sedation protocols in critical care settings, but this specific comparison in severe pneumonia is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
(1)From February 1, 2023, to March 30, 2024, diagnosed with severe pneumonia in the Respiratory Intensive Care Unit of Xiangya Hospital, Central South University. The diagnosis of severe pneumonia is based on meeting at least one major criterion or three or more minor criteria:
1. Major criteria:
①Infectious shock requiring vasopressor therapy despite adequate fluid resuscitation;②Respiratory failure requiring tracheal intubation or mechanical ventilation.
2. Minor criteria:
* Respiratory rate ≥ 30 breaths/min; ②Oxygenation index (PaO2/FiO2) ≤ 250;
* Involvement of multiple lobes; ④Altered mental status and/or disorientation; ⑤Blood urea nitrogen ≥ 20 mg/dl (7.14 mmol/L); ⑥Systolic blood pressure \< 90 mmHg requiring aggressive fluid resuscitation. (2)Patients receiving mechanical ventilation who require sedation treatment. (3)Age ≥ 18 years.
Exclusion Criteria:
1. Allergic to routine sedative or analgesic medications.
2. Patients who have not undergone pain and sedation assessment.
3. Patients transferred to another hospital during treatment.
4. Patients who abandon treatment and are discharged within less than 72 hours of treatment.
Where this trial is running
Changsha, Hunan
- Xiangya Hospital Central South University — Changsha, Hunan, China (Recruiting)
Study contacts
- Study coordinator: Yuanyuan Li, Doctor
- Email: Leeround@csu.edu.cn
- Phone: 13975806790
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.